Median preoptic area neurons are required for the cooling and febrile activations of brown adipose tissue thermogenesis in rat.
Autor: | da Conceição EPS; Department of Neurological Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239-3098, USA., Morrison SF; Department of Neurological Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239-3098, USA., Cano G; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, 15260, USA., Chiavetta P; Department of Neurological Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239-3098, USA., Tupone D; Department of Neurological Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239-3098, USA. domenico.tupone@gmail.com.; Department of Biomedical and Neuromotor Science, University of Bologna, 40126, Bologna, Italy. domenico.tupone@gmail.com. |
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Jazyk: | angličtina |
Zdroj: | Scientific reports [Sci Rep] 2020 Oct 22; Vol. 10 (1), pp. 18072. Date of Electronic Publication: 2020 Oct 22. |
DOI: | 10.1038/s41598-020-74272-w |
Abstrakt: | Within the central neural circuitry for thermoregulation, the balance between excitatory and inhibitory inputs to the dorsomedial hypothalamus (DMH) determines the level of activation of brown adipose tissue (BAT) thermogenesis. We employed neuroanatomical and in vivo electrophysiological techniques to identify a source of excitation to thermogenesis-promoting neurons in the DMH that is required for cold defense and fever. Inhibition of median preoptic area (MnPO) neurons blocked the BAT thermogenic responses during both PGE |
Databáze: | MEDLINE |
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