| Autor: |
Duong VK; SSPC, the SFI Research Centre for Pharmaceuticals, Centre for Synthesis & Chemical Biology, UCD School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland., Horan AM; SSPC, the SFI Research Centre for Pharmaceuticals, Centre for Synthesis & Chemical Biology, UCD School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland., McGarrigle EM; SSPC, the SFI Research Centre for Pharmaceuticals, Centre for Synthesis & Chemical Biology, UCD School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland. |
| Abstrakt: |
An S-selective arylation of pyridylsulfides with good functional group tolerance was developed. To demonstrate synthetic utility, the resulting pyridylsulfonium salts were used in a scalable transition-metal-free coupling protocol, yielding functionalized bipyridines with extensive functional group tolerance. This modular methodology permits selective introduction of functional groups from commercially available pyridyl halides, furnishing symmetrical and unsymmetrical 2,2'- and 2,3'-bipyridines. Iterative application of the methodology enabled the synthesis of a functionalized terpyridine with three different pyridine components. |
