Higher Dose Volumes May Be Better for Evaluating Radiation Pneumonitis in Lung Proton Therapy Patients Compared With Traditional Photon-Based Dose Constraints.
Autor: | Harris WB; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania., Zou W; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania., Cheng C; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania., Jain V; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania., Teo BK; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania., Dong L; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania., Feigenberg SJ; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania., Berman AT; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania., Levin WP; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania., Cengel KA; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania., O'Reilly SE; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania. |
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Jazyk: | angličtina |
Zdroj: | Advances in radiation oncology [Adv Radiat Oncol] 2020 Jun 29; Vol. 5 (5), pp. 943-950. Date of Electronic Publication: 2020 Jun 29 (Print Publication: 2020). |
DOI: | 10.1016/j.adro.2020.06.023 |
Abstrakt: | Purpose: The dosimetric parameters used clinically to reduce the likelihood of radiation pneumonitis (RP) for lung cancer radiation therapy have traditionally been V20Gy ≤ 30% to 35% and mean lung dose ≤ 20 to 23 Gy; however, these parameters are derived based on studies from photon therapy. The purpose of this study is to evaluate whether such dosimetric predictors for RP are applicable for locally advanced non-small cell lung cancer (LA-NSCLC) patients treated with proton therapy. Methods and Materials: In the study, 160 (78 photon, 82 proton) patients with LA-NSCLC treated with chemoradiotherapy between 2011 and 2016 were retrospectively identified. Forty (20 photon, 20 proton) patients exhibited grade ≥2 RP after therapy. Dose volume histograms for the uninvolved lung were extracted for each patient. The percent lung volumes receiving above various dose levels were obtained in addition to V20Gy and D Results: The multivariate analysis showed V40Gy and D Conclusions: In addition to V20Gy and D (© 2020 The Authors.) |
Databáze: | MEDLINE |
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