Continuous Aerobic Exercise Prevents Detrimental Remodeling and Right Heart Myocyte Contraction and Calcium Cycling Dysfunction in Pulmonary Artery Hypertension.

Autor:	Silva FJ; Department of Physical Education, Federal University of Viçosa, Viçosa, Brazil., Drummond FR; Department of General Biology, Federal University of Viçosa, Viçosa, Brazil; and., Fidelis MR; Department of Physical Education, Federal University of Viçosa, Viçosa, Brazil., Freitas MO; Department of Physical Education, Federal University of Viçosa, Viçosa, Brazil., Leal TF; Department of Physical Education, Federal University of Viçosa, Viçosa, Brazil., de Rezende LMT; Department of Physical Education, Federal University of Viçosa, Viçosa, Brazil., de Moura AG; Department of Physical Education, Federal University of Viçosa, Viçosa, Brazil., Carlo Reis EC; Department of Veterinary Medicine, Federal University of Viçosa, Viçosa, Brazil., Natali AJ; Department of Physical Education, Federal University of Viçosa, Viçosa, Brazil.
Jazyk:	angličtina
Zdroj:	Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 2021 Jan 01; Vol. 77 (1), pp. 69-78.
DOI:	10.1097/FJC.0000000000000928
Abstrakt:	Abstract: Pulmonary artery hypertension (PAH) imposes right heart and lung detrimental remodeling which impairs cardiac contractility, physical effort tolerance, and survival. The effects of an early moderate-intensity continuous aerobic exercise training on the right ventricle and lung structure, and on contractility and the calcium (Ca2+) transient in isolated myocytes from rats with severe PAH induced by monocrotaline were analyzed. Rats were divided into control sedentary (CS), control exercise (CE), monocrotaline sedentary (MS), and monocrotaline exercise (ME) groups. Animals from control exercise and ME groups underwent a moderate-intensity aerobic exercise on a treadmill (60 min/d; 60% intensity) for 32 days, after a monocrotaline (60 mg/kg body weight i.p.) or saline injection. The pulmonary artery resistance was higher in MS than in control sedentary (1.36-fold) and was reduced by 39.39% in ME compared with MS. Compared with MS, the ME group presented reduced alveolus (17%) and blood vessel (46%) wall, fibrosis (25.37%) and type I collagen content (55.78%), and increased alveolus (52.96%) and blood vessel (146.97%) lumen. In the right ventricle, the ME group exhibited diminished hypertrophy index (25.53%) and type I collagen content (40.42%) and improved myocyte contraction [ie, reduced times to peak (29.27%) and to 50% relax (13.79%)] and intracellular Ca2+ transient [ie, decreased times to peak (16.06%) and to 50% decay (7.41%)] compared with MS. Thus, early moderate-intensity continuous aerobic exercise prevents detrimental remodeling in the right heart and lung increases in the pulmonary artery resistance and dysfunction in single myocyte contraction and Ca2+ cycling in this model. Competing Interests: The authors report no conflicts of interest. (Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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