Lipid-rich Plaques Detected by Near-infrared Spectroscopy Are More Frequently Exposed to High Shear Stress.

Autor: Hartman EMJ; Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands., De Nisco G; PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy., Kok AM; Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands., Hoogendoorn A; Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands., Coenen A; Department of Radiology, Erasmus MC, Rotterdam, The Netherlands., Mastik F; Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands., Korteland SA; Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands., Nieman K; Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands.; Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.; Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Gijsen FJH; Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands., van der Steen AFW; Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands., Daemen J; Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands., Wentzel JJ; Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands. j.wentzel@erasmusmc.nl.
Jazyk: angličtina
Zdroj: Journal of cardiovascular translational research [J Cardiovasc Transl Res] 2021 Jun; Vol. 14 (3), pp. 416-425. Date of Electronic Publication: 2020 Oct 09.
DOI: 10.1007/s12265-020-10072-x
Abstrakt: High wall shear stress (WSS) and near-infrared spectroscopy (NIRS) detected lipid-rich plaque (LRP) are both known to be associated with plaque destabilization and future adverse cardiovascular events. However, knowledge of spatial co-localization of LRP and high WSS is lacking. This study investigated the co-localization of LRP based on NIRS and high WSS. Fifty-three patients presenting acute coronary syndrome underwent NIRS-intravascular-ultrasound (NIRS-IVUS) imaging of a non-culprit coronary artery. WSS was obtained using WSS profiling in 3D-reconstructions of the coronary arteries based on fusion of IVUS-segmented lumen and CT-derived 3D-centerline. Thirty-eight vessels were available for final analysis and divided into 0.5 mm/45° sectors. LRP sectors, as identified by NIRS, were more often colocalized with high WSS than sectors without LRP. Moreover, there was a dose-dependent relationship between lipid content and high WSS exposure. This study is a first step in understanding the evolution of LRPs to vulnerable plaques. Graphical Abstract.
Databáze: MEDLINE
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