Shared Signature of Recent Positive Selection on the TSBP1-BTNL2-HLA-DRA Genes in Five Native Populations from North Borneo.

Autor:	Hoh BP; Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.; Faculty of Medicine and Health Sciences, UCSI University, Jalan Menara Gading, Taman Connaught, Malaysia Cheras, Kuala Lumpur., Zhang X; Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China., Deng L; Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Yuan K; Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Yew CW; Biotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, Kota Kinabalu, Sabah, Malaysia., Saw WY; Department of Statistics and Applied Probability, Faculty of Science, National University of Singapore, Singapore., Hoque MZ; Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Jalan UMS, Kota Kinabalu, Sabah, Malaysia., Aghakhanian F; Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor, Malaysia., Phipps ME; Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor, Malaysia., Teo YY; Department of Statistics and Applied Probability, Faculty of Science, National University of Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.; NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore.; Life Sciences Institute, National University of Singapore, Singapore.; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Subbiah VK; Biotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, Kota Kinabalu, Sabah, Malaysia., Xu S; Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, China.; Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.; Collaborative Innovation Centre of Genetics and Development, Shanghai, China.
Jazyk:	angličtina
Zdroj:	Genome biology and evolution [Genome Biol Evol] 2020 Dec 06; Vol. 12 (12), pp. 2245-2257.
DOI:	10.1093/gbe/evaa207
Abstrakt:	North Borneo (NB) is home to more than 40 native populations. These natives are believed to have undergone local adaptation in response to environmental challenges such as the mosquito-abundant tropical rainforest. We attempted to trace the footprints of natural selection from the genomic data of NB native populations using a panel of ∼2.2 million genome-wide single nucleotide polymorphisms. As a result, an ∼13-kb haplotype in the Major Histocompatibility Complex Class II region encompassing candidate genes TSBP1-BTNL2-HLA-DRA was identified to be undergoing natural selection. This putative signature of positive selection is shared among the five NB populations and is estimated to have arisen ∼5.5 thousand years (∼220 generations) ago, which coincides with the period of Austronesian expansion. Owing to the long history of endemic malaria in NB, the putative signature of positive selection is postulated to be driven by Plasmodium parasite infection. The findings of this study imply that despite high levels of genetic differentiation, the NB populations might have experienced similar local genetic adaptation resulting from stresses of the shared environment. (© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.)
Databáze:	MEDLINE
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