The Peripheral Hearing and Central Auditory Processing Skills of Individuals With Subjective Memory Complaints.

Autor:	Jayakody DMP; Ear Science Institute Australia, Subiaco, WA, Australia.; Ear Sciences Centre Faculty of Health and Medical Sciences, The University of Western Australia, Crawley, WA, Australia., Menegola HK; Ear Science Institute Australia, Subiaco, WA, Australia., Yiannos JM; Ear Science Institute Australia, Subiaco, WA, Australia.; School of Human Sciences, The University of Western Australia, Crawley, WA, Australia., Goodman-Simpson J; Ear Science Institute Australia, Subiaco, WA, Australia., Friedland PL; Department of Otolaryngology Head Neck Skull Base Surgery, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.; School of Medicine, University Notre Dame, Fremantle, WA, Australia., Taddei K; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia., Laws SM; Collaborative Genomics Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.; School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia., Weinborn M; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.; School of Psychological Science, The University of Western Australia, Nedlands, WA, Australia., Martins RN; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia., Sohrabi HR; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.; Centre for Healthy Ageing, School of Psychology and Exercise Science, Murdoch University, Murdoch, WA, Australia.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroscience [Front Neurosci] 2020 Aug 21; Vol. 14, pp. 888. Date of Electronic Publication: 2020 Aug 21 (Print Publication: 2020).
DOI:	10.3389/fnins.2020.00888
Abstrakt:	Purpose: This study examined the central auditory processing (CAP) assessment results of adults between 45 and 85 years of age with probable pre-clinical Alzheimer's disease - i.e., individuals with subjective memory complaints (SMCs) as compared to those who were not reporting significant levels of memory complaints (non-SMCs). It was hypothesized that the SMC group would perform significantly poorer on tests of central auditory skills compared to participants with non-SMCs (control group). Methods: A total of 95 participants were recruited from the larger Western Australia Memory Study and were classified as SMCs ( N = 61; 20 males and 41 females, mean age 71.47 ±7.18 years) and non-SMCs ( N = 34; 10 males, 24 females, mean age 68.85 ±7.69 years). All participants completed a peripheral hearing assessment, a CAP assessment battery including Dichotic Digits, Duration Pattern Test, Dichotic Sentence Identification, Synthetic Sentence Identification with Ipsilateral Competing Message (SSI-ICM) and the Quick-Speech-in-Noise, and a cognitive screening assessment. Results: The SMCs group performed significantly poorer than the control group on SSI-ICM -10 and -20 dB signal-to-noise conditions. No significant differences were found between the two groups on the peripheral hearing threshold measurements and other CAP assessments. Conclusions: The results suggest that individuals with SMCs perform poorly on specific CAP assessments in comparison to the controls. The poor CAP in SMC individuals may result in a higher cost to their finite pool of cognitive resources. The CAP results provide yet another biomarker that supports the hypothesis that SMCs may be a primary indication of neuropathological changes in the brain. Longitudinal follow up of individuals with SMCs, and decreased CAP abilities should inform whether this group is at higher risk of developing dementia as compared to non-SMCs and those SMC individuals without CAP difficulties. (Copyright © 2020 Jayakody, Menegola, Yiannos, Goodman-Simpson, Friedland, Taddei, Laws, Weinborn, Martins and Sohrabi.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu