Prevalence of p16 expression in oropharyngeal squamous cell carcinoma in southern Brazil.

Autor: Girardi FM; Integrated Oncology Center of Ana Nery Hospital, Santa Cruz do Sul, RS, Brazil. Electronic address: Fabiomgirardi@gmail.com., Wagner VP; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil., Martins MD; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil; Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Department of Oral Medicine, Porto Alegre Clinics Hospital (HCPA/UFRGS), Porto Alegre, RS, Brazil., Abentroth AL; Integrated Oncology Center of Ana Nery Hospital, Santa Cruz do Sul, RS, Brazil., Hauth LA; Integrated Oncology Center of Ana Nery Hospital, Santa Cruz do Sul, RS, Brazil.
Jazyk: angličtina
Zdroj: Oral surgery, oral medicine, oral pathology and oral radiology [Oral Surg Oral Med Oral Pathol Oral Radiol] 2020 Dec; Vol. 130 (6), pp. 681-691. Date of Electronic Publication: 2020 Aug 26.
DOI: 10.1016/j.oooo.2020.08.021
Abstrakt: Objective: Our aim was to evaluate the prevalence of human papillomavirus (HPV)-positive tumors in a cohort of patients with oropharyngeal squamous cell carcinoma (OPSCC) at a single center in southern Brazil and determine the short-term prognostic factors in this sample.
Study Design: Ninety-one consecutive patients with newly diagnosed primary OPSCC between January 2017 and December 2019 were retrospectively included. Demographic, clinical, pathologic, and survival data were collected. HPV status was determined by using p16 immunohistochemistry.
Results: The overall prevalence of HPV-positive (HPV+) OPSCC was 20.9%. Patients with HPV+ tumors presented a nodal metastasis as the first clinical sign (P = .02); reported less alcohol (P < .001) and tobacco use (P < .001); exhibited lower tumor stages (P < .001) and higher microscopic grades (P = .01); and had higher chances of having resectable tumors (P = .008). p16-negative status (P = .01); unresectable/inoperable tumors (P < .001); presence of nodal metastasis (P = .005); and higher American Joint Committee on Cancer (AJCC) stage (P = .002) were significantly associated with worse disease-specific survival.
Conclusions: The prevalence of HPV+ OPSCC in southern Brazil is relatively low, and p16-positive status was associated with Better prognosis. Higher AJCC stage, nodal metastasis, and unresectability/inoperability were associated with the highest hazard ratios for death resulting from OPSCC.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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