Intermittently scanned continuous glucose monitoring is associated with high satisfaction but increased HbA1c and weight in well-controlled youth with type 1 diabetes.

Autor:	Charleer S; Endocrinology, University Hospitals Leuven, Leuven, Belgium.; Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium., Gillard P; Endocrinology, University Hospitals Leuven, Leuven, Belgium.; Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium., Vandoorne E; Pediatrics, University Hospitals Leuven, Leuven, Belgium., Cammaerts K; Pediatrics, University Hospitals Leuven, Leuven, Belgium., Mathieu C; Endocrinology, University Hospitals Leuven, Leuven, Belgium.; Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium., Casteels K; Pediatrics, University Hospitals Leuven, Leuven, Belgium.; Development and Regeneration, KU Leuven, Leuven, Belgium.
Jazyk:	angličtina
Zdroj:	Pediatric diabetes [Pediatr Diabetes] 2020 Dec; Vol. 21 (8), pp. 1465-1474. Date of Electronic Publication: 2020 Oct 06.
DOI:	10.1111/pedi.13128
Abstrakt:	Objective: We undertook a 24-month prospective observational single-center real-world trial to study impact of access to intermittently scanned continuous glucose monitoring (isCGM) on quality of life (QOL) and glycemic control of youth with type 1 diabetes (T1D). Methods: Between September 2016 and November 2017, 138 children and adolescents with T1D were recruited. Demographic, metabolic, and QOL data were collected during 24 months of routine follow-up. Primary endpoint was the evolution of QOL, with secondary outcomes change in HbA1c, occurrence of acute diabetes complications, and school absenteeism. Results: Ninety-two percent of participants found isCGM more user-friendly than capillary finger-stick tests and had high treatment satisfaction, without change in diabetes-specific QOL. HbA1c significantly increased from 7.2% (7.0-7.3) (55 mmol/mol [53-56]) at baseline to 7.6% (7.4-7.8) (60 mmol/mol [57-62]) at 12 months (P < .0001) and was unchanged up to 24 months. Overall increase was mainly driven by children with baseline HbA1c <7.0% (<53 mmol/mol). Additionally, BMI adjusted for age was higher at study end. In year before isCGM, 228 days per 100 patient-years of school absenteeism were reported, which dramatically decreased to 13 days per 100 patient-years (P = .016) after 24 months. Parents of children also reported less work absenteeism (P = .011). Conclusion: The use of isCGM by T1D pediatrics is associated with high treatment satisfaction and fewer days of school absence. However, increased HbA1c and weight may reflect a looser lifestyle, with less attention to diet and more avoidance of hypoglycemia. Intensive education specifically focusing on these points may mitigate these issues. (© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze:	MEDLINE
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