Vaccines for COVID-19: perspectives from nucleic acid vaccines to BCG as delivery vector system.

Autor: de Queiroz NMGP; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Marinho FV; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Chagas MA; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Leite LCC; Laboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo, SP, Brazil., Homan EJ; ioGenetics LLC, Madison, WI, USA., de Magalhães MTQ; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Oliveira SC; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT), CNPq/MCT, BA, Brazil. Electronic address: scozeus1@gmail.com.
Jazyk: angličtina
Zdroj: Microbes and infection [Microbes Infect] 2020 Nov - Dec; Vol. 22 (10), pp. 515-524. Date of Electronic Publication: 2020 Sep 19.
DOI: 10.1016/j.micinf.2020.09.004
Abstrakt: This article discusses standard and new disruptive strategies in the race to develop an anti-COVID-19 vaccine. We also included new bioinformatic data from our group mapping immunodominant epitopes and structural analysis of the spike protein. Another innovative approach reviewed here is the use of BCG vaccine as priming strategy and/or delivery system expressing SARS-CoV-2 antigens.
Competing Interests: Declaration of competing interest EJH is an employee and equity holder in ioGenetics LLC. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
(Copyright © 2020 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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