Seasonal variation of human physiology does not influence the harvest of peripheral blood CD34+ cells from unrelated hematopoietic stem cell donors.

Autor: Pruszczyk K; Department of Hematology, Oncology and Internal Medicine, Medical University of Warsaw, Poland. Electronic address: katarzynapruszczyk@gmail.com., Płachta M; Department of Hematology, Oncology and Internal Medicine, Medical University of Warsaw, Poland., Urbanowska E; Department of Hematology, Oncology and Internal Medicine, Medical University of Warsaw, Poland., Król M; Department of Hematology, Oncology and Internal Medicine, Medical University of Warsaw, Poland., Król M; Department of Hematology, Oncology and Internal Medicine, Medical University of Warsaw, Poland., Feliksbrot-Bratosiewicz M; Department of Hematology, Oncology and Internal Medicine, Medical University of Warsaw, Poland., Zborowska H; Department of Laboratory Diagnostics, Medical University of Warsaw, Warsaw, Poland., Wiktor-Jędrzejczak W; Department of Hematology, Oncology and Internal Medicine, Medical University of Warsaw, Poland., Basak G; Department of Hematology, Oncology and Internal Medicine, Medical University of Warsaw, Poland., Snarski E; Department of Hematology, Oncology and Internal Medicine, Medical University of Warsaw, Poland.
Jazyk: angličtina
Zdroj: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis [Transfus Apher Sci] 2020 Dec; Vol. 59 (6), pp. 102917. Date of Electronic Publication: 2020 Sep 02.
DOI: 10.1016/j.transci.2020.102917
Abstrakt: There are many reports on factors predicting the outcome of PBSC (peripheral blood stem cell) mobilization, such as the donor's gender, age, weight, white blood cell count, platelets pre apheresis, LDH and iron status. Although there are reports of seasonal variation in the physiology of the human immune system and hematopoiesis there are no data that such differences play a role in the response to G-CSF in healthy hematopoietic stem cell donors. The response to G-CSF could also impact the collection results during different seasons. To assess the possible impact of seasonal variation we performed a retrospective, single-center analysis of mobilization and harvest of PBSC in 330 healthy unrelated donors. We found no significant differences in the number of CD34+ cells in peripheral blood after G-CSF mobilization and in collection results when all donors were analyzed. In the subgroup of male donors the number of CD34+ stem cells after G-CSF mobilization was higher than average in summer and autumn (p = 0.036), however, it did not translate into clinically relevant differences in stem cell harvest. We conclude that although there is possible seasonal variation in the response to G-CSF in male donors there is no impact on PBSC harvest in healthy unrelated donors.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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