Prognostic significance of 18 F-sodium fluoride in newly diagnosed multiple myeloma patients.

Autor:	Zadeh MZ; Department of Radiology, Hospital of The University of Pennsylvania PA, USA.; Penn Dental School of Medicine, University of Pennsylvania PA, USA., Seraj SM; Department of Radiology, Hospital of The University of Pennsylvania PA, USA., Østergaard B; Department of Hematology, Odense University Hospital Odense, Denmark., Mimms S; MMRC Jackson, MS, USA., Raynor WY; Department of Radiology, Hospital of The University of Pennsylvania PA, USA.; Drexel University College of Medicine Philadelphia, PA, USA., Aly M; Department of Radiology, Hospital of The University of Pennsylvania PA, USA., Borja AJ; Department of Radiology, Hospital of The University of Pennsylvania PA, USA., Arani LS; Department of Radiology, Hospital of The University of Pennsylvania PA, USA., Gerke O; Department of Nuclear Medicine, Odense University Hospital Odense, Denmark., Werner TJ; Department of Radiology, Hospital of The University of Pennsylvania PA, USA., Zhuang H; Children's Hospital of Philadelphia, Division of Nuclear Medicine, Department of Radiology PA, USA., Revheim ME; Division of Radiology and Nuclear Medicine, Oslo University Hospital Oslo, Norway.; Faculty of Medicine, University of Oslo Norway., Abildgaard N; Department of Hematology, Odense University Hospital Odense, Denmark.; Hematology Research Unit, Department of Clinical Research, University of Southern Denmark., Høilund-Carlsen PF; Department of Nuclear Medicine, Odense University Hospital Odense, Denmark., Alavi A; Department of Radiology, Hospital of The University of Pennsylvania PA, USA.
Jazyk:	angličtina
Zdroj:	American journal of nuclear medicine and molecular imaging [Am J Nucl Med Mol Imaging] 2020 Aug 25; Vol. 10 (4), pp. 151-160. Date of Electronic Publication: 2020 Aug 25 (Print Publication: 2020).
Abstrakt:	Focal bone lesions and fractures due to weakened bone are associated with higher morbidity and mortality of multiple myeloma (MM) patients. 18 F-sodium fluoride ( 18 F-NaF) is a sensitive PET radiotracer for detection of abnormal bone metabolism and, therefore, is particularly suited to assess the degree of bone involvement in MM patients. We aimed to investigate the prognostic significance of metabolic active volume (MAV) of 18 F-NaF-avid lesions in MM patients. In addition to MAV, conventional methods of PET quantification, namely SUVmean and SUVmax, were measured in each patient for the purpose of comparison. Thirty-seven newly diagnosed MM patients were included. PET imaging was performed after intravenous administration of 200 MBq NaF. Active bone lesions and fractures on whole-body 18 F-NaF-PET/CT scans were identified. An adaptive thresholding algorithm automatically calculated the total MAV, SUVmean and SUVmax for each patient (ROVER, ABX, Radeberg, Germany). The patients were followed for a median of 39.8 months after treatment (range: 17.8-55.4). The overall survival (OS) of patients with 18 F-NaF-MAV value > 38.65 (36.36% [N of Events/Total N: 4/11]) was significantly shorter than that of patients with 18 F-NaF-MAV value < 38.65 (3.85% [1/26]; P = 0.002). In multivariate forward stepwise (conditional LR) Cox regression analysis of prognostic factors of OS (including 18 F-NaF-MAV (> 38.65 or < 38.65), age, gender, beta-2 microglobulin, and revised international staging system), 18 F-NaF-MAV remained the only significant factor (HR: 14.39, P = 0.02). The results for PFS were not significant. Moreover, Kaplan-Meier analyses of conventional methods of PET quantification did not reveal any statistically significant log-rank p -values. MM patients with high 18 F-NaF-MAV had shorter overall survival, compared to those with low 18 F-NaF-MAV levels (NCT02187731). Competing Interests: None. (AJNMMI Copyright © 2020.)
Databáze:	MEDLINE
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