Sub-basal increases of GABA enhance the synthesis of TNF-α, TGF-β, and IL-1β in the immune system organs of the Nile tilapia.

Autor: Nájera-Martínez M; Instituto Politécnico Nacional, Escuela Nacional de Ciencias Biológicas, Laboratorio de Toxicología Ambiental, Av. Wilfrido Massieu s/n, Unidad Profesional Zacatenco, México City, CP 07738 México., López-Tapia BP; Instituto Politécnico Nacional, Escuela Nacional de Ciencias Biológicas, Laboratorio de Toxicología Ambiental, Av. Wilfrido Massieu s/n, Unidad Profesional Zacatenco, México City, CP 07738 México., Aguilera-Alvarado GP; Universidad Nacional Autónoma de México, Facultad de Química, Departamento de Bioquímica, México., Madera-Sandoval RL; Instituto Politécnico Nacional, Escuela Nacional de Ciencias Biológicas, Laboratorio de Toxicología Ambiental, Av. Wilfrido Massieu s/n, Unidad Profesional Zacatenco, México City, CP 07738 México., Sánchez-Nieto S; Universidad Nacional Autónoma de México, Facultad de Química, Departamento de Bioquímica, México., Giron-Pérez MI; Universidad Autónoma de Nayarit, Laboratorio Nacional para la Investigación en Inocuidad Alimentaria-Unidad Nayarit, Calle Tres s/n, Cd Industrial, Tepic, Nayarit, México., Vega-López A; Instituto Politécnico Nacional, Escuela Nacional de Ciencias Biológicas, Laboratorio de Toxicología Ambiental, Av. Wilfrido Massieu s/n, Unidad Profesional Zacatenco, México City, CP 07738 México. Electronic address: avegadv@yahoo.com.mx.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2020 Nov 15; Vol. 348, pp. 577382. Date of Electronic Publication: 2020 Sep 04.
DOI: 10.1016/j.jneuroim.2020.577382
Abstrakt: The cells of the immune and neuronal systems share different receptors for cytokines or neurotransmitters, producing feedback responses between both systems. Cytokines such as IL-1β and TNF-α can induce inflammation; however, the secretion of these molecules can be modulated by anti-inflammatory cytokines, as is the case for TGF-β, as well as by different hormones or neurotransmitters such as the γ-aminobutyric acid (GABA). In this study, we evaluated the secretion of IL-1β, TNF-α, and TGF-β under basal conditions, in the head of the kidney, spleen, thymus, and serum of the Nile tilapia, as well as their release induced by different sub-basal increases of GABA. We found that at the higher dose of GABA these cytokines were synthesised at a higher concentration compared to the control group. These results may suggest that there is feedback between both systems and that GABA plays a role in the modulation of the immune response.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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