Prophylaxis of Upper Airway Infections in a Patient with Partial IgA Deficiency: Concurrent Use of Sublingual Immunotherapy with Inactivated Whole-Cell Bacterial Extract and Der p1.

Autor: Aarestrup PF; Universidade Federal do Rio de Janeiro-UNIRIO, Rio de Janeiro, Brazil., Aarestrup MF; Instituto de Ensino Superior Tancredo Neves-IPTAN, São João Del Rei, Minas Gerais, Brazil., Aarestrup BJV; Laboratory of Immunopathology and Experimental Pathology (CBR), Department of Morphology (ICB), Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil., Aarestrup FM; Chairman Laboratory of Immunopathology and Experimental Pathology (CBR), Universidade Federal de Juiz de Fora, Chief Allergy and Immunology Service, Faculdade de Ciências Médicas e da Saúde - SUPREMA e Hospital Maternidade Therezinha de Jesus, Juiz de Fora, Minas Gerais, Brazil.
Jazyk: angličtina
Zdroj: Case reports in otolaryngology [Case Rep Otolaryngol] 2020 Aug 24; Vol. 2020, pp. 6313176. Date of Electronic Publication: 2020 Aug 24 (Print Publication: 2020).
DOI: 10.1155/2020/6313176
Abstrakt: Selective IgA deficiency is the most common type of primary immunodeficiency, but there is not yet a specific effective treatment. The most prevalent clinical manifestations are infectious diseases of the respiratory system. We report herein the case of an 11-year-old female with selective IgA deficiency and recurring episodes of respiratory infections associated with rhinitis and asthma. We evaluated the efficacy of sublingual immunotherapy combined with inactivated whole-cell bacterial extract and Der p1-specific immunotherapy. After 18 months of clinical follow-up, we observed a significant reduction in the number of episodes of respiratory infections associated with control of atopic diseases. We also observed a 3-fold increase in serum IgA levels compared to treatment initiation. This case demonstrates the potential utility of the concurrent use of sublingual immunotherapy with inactivated whole-cell bacterial extract and Der p1 for successful control of allergy and infection in partial selective IgA deficiency.
Competing Interests: The authors declare that there are no conflicts of interest regarding the publication of this paper.
(Copyright © 2020 Paula F. Aarestrup et al.)
Databáze: MEDLINE
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