Goat Genomic Resources: The Search for Genes Associated with Its Economic Traits.

Autor: Zonaed Siddiki AMAM; Genomics Research Group, Faculty of Veterinary Medicine, Chattogram Veterinary and Animal Sciences University (CVASU), Chattogram 4225, Bangladesh., Miah G; Department of Genetics and Animal Breeding, Faculty of Veterinary Medicine, Chattogram Veterinary and Animal Sciences University (CVASU), Chattogram 4225, Bangladesh., Islam MS; Genomics Research Group, Faculty of Veterinary Medicine, Chattogram Veterinary and Animal Sciences University (CVASU), Chattogram 4225, Bangladesh., Kumkum M; Human Biology-Principles of Health and Disease, Ludwig Maximilians University, Munich, Germany., Rumi MH; Genomics Research Group, Faculty of Veterinary Medicine, Chattogram Veterinary and Animal Sciences University (CVASU), Chattogram 4225, Bangladesh., Baten A; AgResearch, Palmerston North 4410, Private Bag 11008, New Zealand., Hossain MA; Department of Pathology and Parasitology, Faculty of Veterinary Medicine, Chattogram Veterinary and Animal Sciences University (CVASU), Chattogram 4225, Bangladesh.
Jazyk: angličtina
Zdroj: International journal of genomics [Int J Genomics] 2020 Aug 18; Vol. 2020, pp. 5940205. Date of Electronic Publication: 2020 Aug 18 (Print Publication: 2020).
DOI: 10.1155/2020/5940205
Abstrakt: Goat plays a crucial role in human livelihoods, being a major source of meat, milk, fiber, and hides, particularly under adverse climatic conditions. The goat genomics related to the candidate gene approach is now being used to recognize molecular mechanisms that have different expressions of growth, reproductive, milk, wool, and disease resistance. The appropriate literature on this topic has been reviewed in this article. Several genetic characterization attempts of different goats have reported the existence of genotypic and morphological variations between different goat populations. As a result, different whole-genome sequences along with annotated gene sequences, gene function, and other genomic information of different goats are available in different databases. The main objective of this review is to search the genes associated with economic traits in goats. More than 271 candidate genes have been discovered in goats. Candidate genes influence the physiological pathway, metabolism, and expression of phenotypes. These genes have different functions on economically important traits. Some genes have pleiotropic effect for expression of phenotypic traits. Hence, recognizing candidate genes and their mutations that cause variations in gene expression and phenotype of an economic trait can help breeders look for genetic markers for specific economic traits. The availability of reference whole-genome assembly of goats, annotated genes, and transcriptomics makes comparative genomics a useful tool for systemic genetic upgradation. Identification and characterization of trait-associated sequence variations and gene will provide powerful means to give positive influences for future goat breeding program.
Competing Interests: The authors declare that there is no conflict of interest.
(Copyright © 2020 A. M. A. M. Zonaed Siddiki et al.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje