Survival benefit of renal transplantation in octogenarians.

Autor: Ravichandran BR; Department of Pharmacy, University of Maryland Medical Center, Baltimore, MD, USA., Sparkes TM; Department of Pharmacy, University of Maryland Medical Center, Baltimore, MD, USA., Masters BM; Department of Pharmacy, University of Maryland Medical Center, Baltimore, MD, USA., Thomas B; Department of Nephrology, University of Maryland School of Medicine, Baltimore, MD, USA., Demehin M; Department of Pharmacy, University of Maryland Medical Center, Baltimore, MD, USA., Bromberg JS; Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA., Haririan A; Department of Nephrology, University of Maryland School of Medicine, Baltimore, MD, USA.
Jazyk: angličtina
Zdroj: Clinical transplantation [Clin Transplant] 2020 Nov; Vol. 34 (11), pp. e14074. Date of Electronic Publication: 2020 Sep 27.
DOI: 10.1111/ctr.14074
Abstrakt: Background: Elderly patients are the fastest growing population requiring renal replacement therapy. As previous studies have shown a survival benefit of kidney transplantation compared to dialysis for end-stage renal disease, we sought to evaluate if this survival benefit extends to octogenarians.
Methods: This was a single-center retrospective cohort study of renal allograft recipients ≥80 years transplanted from 1999 to 2014 who were compared to patients listed during the same period that did not proceed to transplantation. A secondary matched group was selected from the UNOS transplant waitlist database. The primary outcome was patient survival. Secondary outcomes included graft survival and rejection incidence.
Results: Thirty-three transplanted patients were compared to 71 patients waitlisted at our center and 66 patients from the UNOS database. Patients in the study group were transplanted 20.8 ± 16.1 months after listing. Patient survival was 87.8% at 6 months and 1 year and 71.4% at 3 years. Kidney transplantation was associated with a significant decrease in the risk of death after listing (HR: 0.22, CI: 0.11-0.45, P < .001).
Conclusion: With escalating life expectancy, kidney transplantation is a suitable treatment option in eligible octogenarians.
(© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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