| Autor: |
Wray C, Sojka WJ, Morris JA, Brinley Morgan WJ |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of hygiene [J Hyg (Lond)] 1977 Aug; Vol. 79 (1), pp. 17-24. |
| DOI: |
10.1017/s0022172400052803 |
| Abstrakt: |
A galactose epimeraseless (gal E) mutant of Salmonella typhimurium was investigated in mice and calves for its suitability as a live vaccine. In mice, a very highly significant difference in the mortality rates was observed when vaccinated and non-vaccinated animals were challenged with virulent strains of S. typhimurium and S. dublin. In calves, doses of 10(6) and above of gal E mutant injected subcutaneously provided highly significant protection both in terms of mortality and prevalence of symptoms when calves were challenged orally with S. typhimurium. However, there appeared to be a relation between the vaccine and the presence of renal lesions and before gal E mutants can be recommended, further work is necessary to determine the pathogenesis of these lesions. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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