ABO-nonidentical liver transplantation from a deceased donor and clinical outcomes following antibody rebound: A case report.
| Autor: | Peruhova M; Department of Gastroenterology, University Hospital Lozenetz, Sofia 1407, Bulgaria., Georgieva V; Department of Gastroenterology, University Hospital Lozenetz, Sofia 1407, Bulgaria., Yurukova N; Department of Gastroenterology, University Hospital Lozenetz, Sofia 1407, Bulgaria., Sekulovska M; Department of Gastroenterology, University Hospital Lozenetz, Sofia 1407, Bulgaria., Panayotova G; Department of Gastroenterology, University Hospital Lozenetz, Sofia 1407, Bulgaria., Mihova A; Department of Clinical Immunology, University Hospital Lozenetz, Sofia 1407, Bulgaria., Terzieva V; Department of Clinical Immunology, University Hospital Lozenetz, Sofia 1407, Bulgaria., Velikova TV; Department of Clinical Immunology, University Hospital Lozenetz, Sofia 1407, Bulgaria. tsvelikova@medfac.mu-sofia.bg. |
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| Jazyk: | angličtina |
| Zdroj: | World journal of transplantation [World J Transplant] 2020 May 29; Vol. 10 (5), pp. 138-146. |
| DOI: | 10.5500/wjt.v10.i5.138 |
| Abstrakt: | Background: Although ABO-nonidentical and ABO-incompatible liver transplantation (LT) are other options for end-stage liver disease treatment, the development of antibodies against blood group antigens (anti-A/B antibodies) is still a challenge in managing and follow-up of the recipients. Case Summary: A 56-year-old male with end-stage liver disease with rapid deterioration and poor prognosis was considered to receive a deceased ABO-nonidentical liver graft. All required tests were performed according to our pre-LT diagnostic protocol. The orthotopic LT procedure involving O+ donor and A1B+ recipient was performed. Our treatment strategy to overcome the antibody-mediated rejection included a systemic triple immunosuppressive regimen: methylprednisolone, mycophenolate mofetil, and tacrolimus. The immunological desensitization consisted of the chimeric anti-CD20 monoclonal antibody rituximab and intravenous immunoglobulins. The patient was also on antibiotic treatment with amoxicillin/clavulanate, cefotaxime, and metronidazole. On the 10 th postoperative day, high titers of IgG anti-A and anti-B antibodies were found in the patient's plasma. We performed a liver biopsy, which revealed histological evidence of antibody-mediated rejection, but the rejection was excluded according to the Banff classification. The therapy was continued until the titer decreased significantly on the 18 th postoperative day. Despite the antibiotic, antifungal, and antiviral treatment, the patient deteriorated and developed septic shock with anuria and pancytopenia. The conservative treatment was unsuccessful, which lead to the patient's fatal outcome on the 42 nd postoperative day. Conclusion: We present a patient who underwent ABO-nonidentical LT from a deceased donor. Even though we implemented the latest technological advancements and therapeutic approaches in the management of the patient and the initial results were promising, due to severe infectious complications, the outcome was fatal. Competing Interests: Conflict-of-interest statement: The authors declare no conflict of interest. (©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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