Mortality Over Long-term Follow-up for People With HIV Receiving Longitudinal Care and Antiretroviral Therapy in Rural Haiti.

Autor: Richterman A; Division of Infectious Diseases, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Leandre F; Zanmi Lasante/Partners In Health, Cange, Haiti.; Division of Global Health Equity, Brigham and Women Hospital, Boston, Massachusetts, USA., Jerome JG; Zanmi Lasante/Partners In Health, Cange, Haiti., Tsai AC; Center for Global Health, Massachusetts General Hospital, Boston, Massachusetts, USA., Ivers LC; Center for Global Health, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Jazyk: angličtina
Zdroj: Open forum infectious diseases [Open Forum Infect Dis] 2020 Aug 11; Vol. 7 (8), pp. ofaa328. Date of Electronic Publication: 2020 Aug 11 (Print Publication: 2020).
DOI: 10.1093/ofid/ofaa328
Abstrakt: Background: Deaths from HIV have fallen dramatically with the increasing availability of fully suppressive antiretroviral therapy (ART), and yet HIV remains the ninth leading cause of death in low-income countries. As more people with HIV enter care and receive ART, the focus will need to shift from expanding ART to including long-term program effectiveness and outcomes for people with HIV already engaged in care.
Methods: We evaluated risk factors for mortality among people with HIV on ART receiving longitudinal care in rural Haiti. We assessed baseline characteristics using a household survey and abstracted clinical characteristics from the electronic record. We used multivariable Cox regression models to identify risk factors for mortality.
Results: There were 464 people included in this study with a median follow-up (interquartile range [IQR]) of 69 (44-77) months, during which time 37 (8%) were lost to follow-up and 118 (25%) died (median time to death [IQR], 29 [12-53] months). After adjustment, poverty (adjusted hazard ratio [AHR], 1.12 per 10-percentage point increased probability; 95% CI, 1.01-1.24) and single marital status (AHR, 1.59; 95% CI, 1.08-2.36) were associated with increased mortality. Age (AHR, 0.78 per 10-year increase; 95% CI, 0.64-0.94), role function quality of life (AHR, 0.75 per quintile increase; 95% CI, 0.62-0.90), and CD4 count (AHR, 0.66 per 100 cells/μL; 95% CI, 0.58-0.75) were associated with decreased mortality.
Conclusions: Poverty, marital status, and quality of life were associated with mortality. Social protection should be evaluated as a strategy to reduce mortality for people with HIV in concert with increasing access to ART.
(© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje