[Association between vitamin D status and CYP27b1 and CYP24A1 gene polymorphisms in patients with multiple sclerosis in the Altai region].

Autor:	Smagina IV; Altai State Medical University, Barnaul, Russia.; Regional Clinical Hospital, Barnaul, Russia., Lunev KV; Altai State Medical University, Barnaul, Russia., Elchaninova SA; Altai State Medical University, Barnaul, Russia.
Jazyk:	ruština
Zdroj:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2020; Vol. 120 (7. Vyp. 2), pp. 61-66.
DOI:	10.17116/jnevro202012007261
Abstrakt:	Multiple sclerosis (MS) is often accompanied by a deficiency of vitamin D, the causes of which are not exactly clear how. It is suggested that this may be due to genetically determined characteristics of enzymes of vitamin D3 metabolism in patients with MS. Objective: To evaluate the relationship between vitamin D status and polymorphisms of the genes encoding enzymes of the vitamin D metabolism CYP27B1 (rs703842) and CYP24A1 (rs2248359) in patients with MS. Material and Methods: Caucasians born and living in the Altai region of the Russian Federation, 90 patients with relapsing-remitting MS and 87 volunteers without MS took part in the study. The level of 25-hydroxyvitamin D (25(OH)D) in the blood serum was measured by enzyme immunoassay. Genotyping was carried out using the TaqMan probe method. Results: A level of 25(OH)D of less than 30 ng/ml was more common among patients with MS compared with the control. A relationship between the MS risk and the TC genotype CYP27B1 (rs703842) was identified. In patients with MS and in the control, the GA genotype CYP24A1 (rs2248359) was associated with a 25(OH)D level of less than 30 ng/ml. Conclusion: The high prevalence of vitamin D deficiency in patients with MS may be associated with the genetically determined features of CYP27B1 .
Databáze:	MEDLINE
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