Mapping mania symptoms based on focal brain damage.

Autor:	Cotovio G; Champalimaud Research and Clinical Centre, Champalimaud Centre for the Unknown, Lisbon, Portugal.; Department of Psychiatry and Mental Health, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.; NOVA Medical School | Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal., Talmasov D; Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Neurology, New York University School of Medicine, New York, New York, USA., Barahona-Corrêa JB; Champalimaud Research and Clinical Centre, Champalimaud Centre for the Unknown, Lisbon, Portugal.; Department of Psychiatry and Mental Health, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.; NOVA Medical School | Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal., Hsu J; Berenson-Allen Center for Non-Invasive Brain Stimulation and.; Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Senova S; Champalimaud Research and Clinical Centre, Champalimaud Centre for the Unknown, Lisbon, Portugal.; Neurosurgery Department and.; PePsy Department, Groupe Henri-Mondor Albert-Chenevier, Assistance Publique-Hôpitaux de Paris (APHP), Créteil, France.; Equipe 14, U955 INSERM, Institut Mondor de Recherche Biomedicale and.; Faculté de Médecine, Université Paris Est, Créteil, France., Ribeiro R; Champalimaud Research and Clinical Centre, Champalimaud Centre for the Unknown, Lisbon, Portugal., Soussand L; Berenson-Allen Center for Non-Invasive Brain Stimulation and.; Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Velosa A; Department of Psychiatry and Mental Health, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal., Silva VCE; Department of Neuroradiology, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal., Rost N; J. Philip Kistler Stroke Research Center, Department of Neurology and., Wu O; Athinoula A. Martinos Centre for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital., Cohen AL; Berenson-Allen Center for Non-Invasive Brain Stimulation and.; Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.; Department of Neurology, Boston Children's Hospital, and., Oliveira-Maia AJ; Champalimaud Research and Clinical Centre, Champalimaud Centre for the Unknown, Lisbon, Portugal.; Department of Psychiatry and Mental Health, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.; NOVA Medical School | Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal., Fox MD; Berenson-Allen Center for Non-Invasive Brain Stimulation and.; Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.; Athinoula A. Martinos Centre for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital.; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Center for Brain Circuit Therapeutics, Department of Neurology, Department of Psychiatry, Department of Neurosurgery, and Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Jazyk:	angličtina
Zdroj:	The Journal of clinical investigation [J Clin Invest] 2020 Oct 01; Vol. 130 (10), pp. 5209-5222.
DOI:	10.1172/JCI136096
Abstrakt:	BACKGROUNDAlthough mania is characteristic of bipolar disorder, it can also occur following focal brain damage. Such cases may provide unique insight into brain regions responsible for mania symptoms and identify therapeutic targets.METHODSLesion locations associated with mania were identified using a systematic literature search (n = 41) and mapped onto a common brain atlas. The network of brain regions functionally connected to each lesion location was computed using normative human connectome data (resting-state functional MRI, n = 1000) and contrasted with those obtained from lesion locations not associated with mania (n = 79). Reproducibility was assessed using independent cohorts of mania lesions derived from clinical chart review (n = 15) and of control lesions (n = 490). Results were compared with brain stimulation sites previously reported to induce or relieve mania symptoms.RESULTSLesion locations associated with mania were heterogeneous and no single brain region was lesioned in all, or even most, cases. However, these lesion locations showed a unique pattern of functional connectivity to the right orbitofrontal cortex, right inferior temporal gyrus, and right frontal pole. This connectivity profile was reproducible across independent lesion cohorts and aligned with the effects of therapeutic brain stimulation on mania symptoms.CONCLUSIONBrain lesions associated with mania are characterized by a specific pattern of brain connectivity that lends insight into localization of mania symptoms and potential therapeutic targets.FUNDINGFundação para a Ciência e Tecnologia (FCT), Harvard Medical School DuPont-Warren Fellowship, Portuguese national funds from FCT and Fundo Europeu de Desenvolvimento Regional, Child Neurology Foundation Shields Research, Sidney R. Baer, Jr. Foundation, Nancy Lurie Marks Foundation, Mather's Foundation, and the NIH.
Databáze:	MEDLINE
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