The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study.

Autor: Rajković-Molek K; Clinical Department of Pathology and Cytology, Clinical Hospital Center Rijeka, Krešimirova 42, 51000 Rijeka, Croatia. Electronic address: koraljka.rajkovic@ri.t-com.hr., Mustać E; Clinical Department of Pathology and Cytology, Clinical Hospital Center Rijeka, Krešimirova 42, 51000 Rijeka, Croatia; Department of Pathology, Faculty of Medicine, University of Rijeka, Brace Branchetta 20, 51000 Rijeka, Croatia. Electronic address: elvira.mustac@uniri.hr., Avirović M; Clinical Department of Pathology and Cytology, Clinical Hospital Center Rijeka, Krešimirova 42, 51000 Rijeka, Croatia; Department of Pathology, Faculty of Medicine, University of Rijeka, Brace Branchetta 20, 51000 Rijeka, Croatia. Electronic address: manuela.avirovic@uniri.hr., Georgev P; Faculty of Medicine, University of Rijeka, Brace Branchetta 20, 51000 Rijeka, Croatia. Electronic address: paula.georgev@gmail.com., Demaria M; Faculty of Medicine, University of Rijeka, Brace Branchetta 20, 51000 Rijeka, Croatia. Electronic address: martina.demaria2@gmail.com., Aničić J; Faculty of Medicine, University of Rijeka, Brace Branchetta 20, 51000 Rijeka, Croatia. Electronic address: josip.anicic@gmail.com., Ban J; Faculty of Medicine, University of Rijeka, Brace Branchetta 20, 51000 Rijeka, Croatia. Electronic address: jban9924@gmail.com., Babarović E; Department of Pathology, Faculty of Medicine, University of Rijeka, Brace Branchetta 20, 51000 Rijeka, Croatia. Electronic address: esinozic@gmail.com.
Jazyk: angličtina
Zdroj: Pathology, research and practice [Pathol Res Pract] 2020 Sep; Vol. 216 (9), pp. 153068. Date of Electronic Publication: 2020 Jun 20.
DOI: 10.1016/j.prp.2020.153068
Abstrakt: Breast cancer is a heterogeneous disease with different biological outcome and ability to acquire resistance to therapy. The calpain family of proteases and androgen receptor (AR) are implicated in breast cancer pathogenesis and progression and are potential targets for novel treatment regimens. The aim of this study was to investigate the expression of calpain-1 and AR in breast cancer and to correlate their expression with clinicopathological variables and prognosis of patients. In this study we enrolled 219 breast cancer patients with long term follow-up information available. Immunohistochemical methods on a tissue microarray were used to investigate expression of calpain-1 and AR in tumor cells. The expression of calpain-1 and AR both differed significantly between the tumor subtypes of patients (p = 0.002 and p = 0.042 respectively). High calpain-1 expression was associated with patient's age over 50 years (p = 0.005) and positive ER status (p = 0.009), but not with other clinicopathological variables. Women with AR negative breast cancers were more likely to be older (p = 0.016), to have bigger tumors (p = 0.032), higher stage of the disease (p = 0.026), presence of exulceration (p = 0.017), negative ER status (p = 0.007) and higher Ki-67 proliferative index (p = 0.027). Calpain-1 expression was not associated with breast cancer specific overall survival in the total cohort of patients, however low calpain-1 expression was associated with adverse survival (p = 0.018) in triple negative subgroup of patients. Low calpain-1 expression was also associated with significantly shorter 5-year disease-free survival in total cohort of patients (p = 0.03). AR status was not associated with overall and disease-free survival of patients. This study has demonstrated that the expression of calpain-1 and androgen receptors are associated with important clinicopathological variables. The expression of calpain-1 was associated with improved disease-free survival of all analyzed patients and with improved overall survival of triple negative breast cancer patients.
(Copyright © 2020 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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