Redox Status, Dose and Antioxidant Intake in Healthcare Workers Occupationally Exposed to Ionizing Radiation.

Autor:	Sebastià N; Service of Radiological Protection, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain.; Biomedical Imaging Research Group GIBI230, Avda. Fernando Abril Martorell, 106, Health Research Institute Hospital La Fe (IISLaFe), 46026 Valencia, Spain., Olivares-González L; Pathophysiology and Therapies for Visual Disorders, Eduardo Primo Yúfera, 3, Research Center Príncipe Felipe (CIPF), 46012 Valencia, Spain.; Center for Biomedical Network Research on Rare Diseases (CIBERER), Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain., Montoro A; Service of Radiological Protection, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain.; Biomedical Imaging Research Group GIBI230, Avda. Fernando Abril Martorell, 106, Health Research Institute Hospital La Fe (IISLaFe), 46026 Valencia, Spain., Barquinero JF; Biological Anthropology Unit Animal Biology, Plant Biology and Ecology Department, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Spain., Canyada-Martinez AJ; Biostatistics Unit, Avda. Fernando Abril Martorell, 106, Health Research Institute Hospital La Fe (IISLaFe), 46026 Valencia, Spain., Hervás D; Biostatistics Unit, Avda. Fernando Abril Martorell, 106, Health Research Institute Hospital La Fe (IISLaFe), 46026 Valencia, Spain., Gras P; Service of Radiological Protection, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain., Villaescusa JI; Service of Radiological Protection, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain.; Biomedical Imaging Research Group GIBI230, Avda. Fernando Abril Martorell, 106, Health Research Institute Hospital La Fe (IISLaFe), 46026 Valencia, Spain., Martí-Bonmatí L; Biomedical Imaging Research Group GIBI230, Avda. Fernando Abril Martorell, 106, Health Research Institute Hospital La Fe (IISLaFe), 46026 Valencia, Spain.; Service of Radiology, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain., Muresan BT; Service of Radiological Protection, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain., Soriano JM; Food & Health Lab, Institute of Materials Science, Parc Científic, Catedrático Agustín Escardino, Paterna (Valencia), University of Valencia, 46980 Valencia, Spain.; Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, University of Valencia, Avda. Fernando Abril Martorell, 106, Health Research Institute Hospital La Fe (IISLaFe), 46026 Valencia, Spain., Campayo JM; Service of Radiological Protection, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain., Andani J; Service of Occupational Risk Prevention, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain., Alonso O; Service of Radiological Protection, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain., Rodrigo R; Pathophysiology and Therapies for Visual Disorders, Eduardo Primo Yúfera, 3, Research Center Príncipe Felipe (CIPF), 46012 Valencia, Spain.; Center for Biomedical Network Research on Rare Diseases (CIBERER), Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain.; Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, University of Valencia, Avda. Fernando Abril Martorell, 106, Health Research Institute Hospital La Fe (IISLaFe), 46026 Valencia, Spain.; Joint Research Unit of Rare Diseases, CIPF-Health Research Institute La Fe, Eduardo Primo Yúfera, 3, 46012 Valencia, Spain.
Jazyk:	angličtina
Zdroj:	Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2020 Aug 21; Vol. 9 (9). Date of Electronic Publication: 2020 Aug 21.
DOI:	10.3390/antiox9090778
Abstrakt:	The purpose of this study was to evaluate the relationship between blood redox status, dose and antioxidant dietary intake of different hospital staff groups exposed to low doses of ionizing radiation (LDIR) (Interventional Radiology and Cardiology, Radiation Oncology, and Nuclear Medicine) and non-exposed. Personal dose equivalent (from last year and cumulative), plasma antioxidant markers (total antioxidant capacity, extracellular superoxide dismutase activity, and glutathione/oxidized glutathione ratio), oxidative stress markers (nitrites and nitrates, and lipid peroxidation) and dietary intake (antioxidant capacity using ORAC values) were collected and analyzed from 28 non-exposed healthcare workers and 42 healthcare workers exposed to LDIR. Hospital staff exposed to LDIR presented a redox imbalance in blood that seems to correlate with dose. Workers from the Nuclear Medicine Unit were the most affected group with the lowest value of plasma antioxidant response and the highest value of plasma thiobarbituric acid reactive substances, TBARS (indicator of lipid peroxidation) of all four groups. Cumulative personal dose equivalent positively correlated with nitrites and negatively correlated with total antioxidant capacity in blood. The diet of healthcare workers from Nuclear Medicine Unit had higher ORAC values than the diet of non-exposed. Therefore, occupational exposure to LDIR, especially for the Nuclear Medicine Unit, seems to produce an imbalanced redox status in blood that would correlate with cumulative personal dose equivalent.
Databáze:	MEDLINE
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