Functional Mammalian Amyloids and Amyloid-Like Proteins.

Autor: Rubel MS; SCAMT Institute, ITMO University, 191002 St. Petersburg, Russia., Fedotov SA; Laboratory of Amyloid Biology, St. Petersburg State University, 199034 St. Petersburg, Russia.; Pavlov Institute of Physiology, Russian Academy of Sciences, 199034 St. Petersburg, Russia., Grizel AV; Laboratory of Amyloid Biology, St. Petersburg State University, 199034 St. Petersburg, Russia., Sopova JV; Laboratory of Amyloid Biology, St. Petersburg State University, 199034 St. Petersburg, Russia.; St. Petersburg Branch, N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, 199034 St. Petersburg, Russia.; Department of Genetics and Biotechnology, St. Petersburg State University, 199034 St. Petersburg, Russia., Malikova OA; Laboratory of Amyloid Biology, St. Petersburg State University, 199034 St. Petersburg, Russia., Chernoff YO; Laboratory of Amyloid Biology, St. Petersburg State University, 199034 St. Petersburg, Russia.; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332-2000, USA., Rubel AA; Laboratory of Amyloid Biology, St. Petersburg State University, 199034 St. Petersburg, Russia.; Department of Genetics and Biotechnology, St. Petersburg State University, 199034 St. Petersburg, Russia.
Jazyk: angličtina
Zdroj: Life (Basel, Switzerland) [Life (Basel)] 2020 Aug 21; Vol. 10 (9). Date of Electronic Publication: 2020 Aug 21.
DOI: 10.3390/life10090156
Abstrakt: Amyloids are highly ordered fibrous cross-β protein aggregates that are notorious primarily because of association with a variety of incurable human and animal diseases (termed amyloidoses), including Alzheimer's disease (AD), Parkinson's disease (PD), type 2 diabetes (T2D), and prion diseases. Some amyloid-associated diseases, in particular T2D and AD, are widespread and affect hundreds of millions of people all over the world. However, recently it has become evident that many amyloids, termed "functional amyloids," are involved in various activities that are beneficial to organisms. Functional amyloids were discovered in diverse taxa, ranging from bacteria to mammals. These amyloids are involved in vital biological functions such as long-term memory, storage of peptide hormones and scaffolding melanin polymerization in animals, substrate attachment, and biofilm formation in bacteria and fungi, etc. Thus, amyloids undoubtedly are playing important roles in biological and pathological processes. This review is focused on functional amyloids in mammals and summarizes approaches used for identifying new potentially amyloidogenic proteins and domains.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
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