| Autor: |
Sakthivel A; Department of Chemistry, Mepco Schlenk Engineering College, Sivakasi, India., Thangagiri B; Department of Chemistry, Mepco Schlenk Engineering College, Sivakasi, India., Raman N; Research Department of Chemistry, VHNSN College, Virudhunagar, India., Joseph J; Department of Chemistry, Noorul Islam Centre for Higher Education, Kumaracoil, Tamil Nadu, India., Guda R; Department of Chemistry, Kakatiya University, Warangal, India., Kasula M; Department of Chemistry, Kakatiya University, Warangal, India., Mitu L; Department of Nature Sciences, University of Pitesti, Pitesti, Romania. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2021 Oct; Vol. 39 (17), pp. 6500-6514. Date of Electronic Publication: 2020 Aug 14. |
| DOI: |
10.1080/07391102.2020.1801508 |
| Abstrakt: |
Novel macrocyclic Schiff base complexes [[ML]X; where M = Cu(II), Co(II), Ni(II), Zn(II), Mn(II) and VO(IV) ; L = macrocyclic ligand; X = Cl 2 and SO 4 2- ] have been synthesized and characterized by microanalytical, 1 H, 13 C NMR, IR, Mass, UV-Vis, EPR spectral studies, as well as conductivity data. All the complexes exhibit square-planar geometry except vanadium complex. Magnetic susceptibility measurements and high conductance data reveal the monomeric and electrolytic nature of the complexes. Electronic absorption, cyclic voltammetry, viscosity measurements have been carried out on the interaction of the complexes with DNA. The results suggest that the complexes bind to DNA by intercalation via the aromatic ring of the macrocycle into the base pairs of DNA. Using gel electrophoresis experiment in the presence and absence of oxidant (H 2 O 2 ) the nuclease cleavage activity of the complexes has been performed on plasmid DNA. The results demonstrate that most of the complexes have promising superoxide dismutase (SOD)-mimetic activity. The in vitro cytotoxicity of ligand and its complexes has also been evaluated against human breast and colon carcinoma cells. Binding interactions and energies of ligand and its metal complexes [ML] 2+ (M = VO(IV), Mn(II), Co(II), Ni(II), Cu(II), Zn(II)) against the receptors EGFR and HER2 are performed using the Auto dock module. Consequently, it is found that the ligand is strong inhibitor for EGFR and HER2 while [VOL]SO 4 is good inhibitor for EGFR and [ZnL]Cl 2 is moderate inhibitor for HER2. The antimicrobial activity of the ligand and its complexes against bacteria Salmonella typhi , Staphylococcus aureus , Escherichia coli and Bacillus subtilis and fungi Aspergillus niger , Aspergillus flavus , Candida Albicans and Rhizoctonia bataicola. The complexes have higher activities than the macrocyclic free Schiff base. Communicated by Ramaswamy H. Sarma. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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