Circulating microparticle concentrations across acute and chronic cardiovascular disease conditions.

Autor: Landers-Ramos RQ; Department of Kinesiology, Towson University, Towson, MD, USA.; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Baltimore Veterans Affairs Geriatric Research, Education and Clinical Center, Baltimore, MD, USA., Addison OA; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Baltimore Veterans Affairs Geriatric Research, Education and Clinical Center, Baltimore, MD, USA., Beamer B; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Baltimore Veterans Affairs Geriatric Research, Education and Clinical Center, Baltimore, MD, USA., Katzel LI; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Baltimore Veterans Affairs Geriatric Research, Education and Clinical Center, Baltimore, MD, USA., Blumenthal JB; Baltimore Veterans Affairs Geriatric Research, Education and Clinical Center, Baltimore, MD, USA., Robinson S; Baltimore Veterans Affairs Geriatric Research, Education and Clinical Center, Baltimore, MD, USA., Hagberg JM; Department of Kinesiology, University of Maryland, College Park, MD, USA., Prior SJ; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Baltimore Veterans Affairs Geriatric Research, Education and Clinical Center, Baltimore, MD, USA.; Department of Kinesiology, University of Maryland, College Park, MD, USA.
Jazyk: angličtina
Zdroj: Physiological reports [Physiol Rep] 2020 Aug; Vol. 8 (15), pp. e14534.
DOI: 10.14814/phy2.14534
Abstrakt: Concentrations of different circulating microparticles (MPs) may have clinical and physiological relevance to cardiovascular disease pathologies.
Purpose: To quantify plasma concentrations of CD31+/CD42b-, CD62E+, and CD34+ MPs across healthy individuals and those with coronary artery disease (CAD) or acute cardiovascular events (non-ST elevation myocardial infarction (NSTEMI)). Fasted blood was obtained from CAD patients (n = 10), NSTEMI patients (n = 13), and healthy older men (n = 15) 60-75 years old.
Methods: CD31+/CD42b-, CD62E+, and CD34+ MPs were isolated from plasma and quantified using flow cytometry. Relationships between MP subtypes, fasting blood lipids, blood glucose, blood pressure, body mass index, and total number of medications were assessed.
Results: Concentrations of CD31+/CD42b- MPs were significantly lower in CAD and NSTEMI subjects compared with healthy individuals (p = .02 and .003, respectively). No differences between groups were found for CD62E+ or CD34+ MPs (p > .05 for both). Surprisingly, among all variables assessed, only CD62E+ MP concentrations were positively correlated with triglyceride levels (p = .012) and inversely correlated with SBP (p = .03).
Conclusions: Our findings provide support for the use of different MP subtypes, specifically CD31+/CD42b- MPs, as a potential biomarker of cardiovascular disease. Importantly, results from this study should be looked at in adjunct to previous MP work in CVD conditions as a way of highlighting the complex interactions of variables such as comorbid conditions and medications on MP concentrations.
(© 2020 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.)
Databáze: MEDLINE
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