The FDA-approved drugs ticlopidine, sertaconazole, and dexlansoprazole can cause morphological changes in C. elegans.

Autor: Galford KF; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742, USA., Jose AM; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742, USA. Electronic address: amjose@umd.edu.
Jazyk: angličtina
Zdroj: Chemosphere [Chemosphere] 2020 Dec; Vol. 261, pp. 127756. Date of Electronic Publication: 2020 Jul 23.
DOI: 10.1016/j.chemosphere.2020.127756
Abstrakt: Urgent need for treatments limit studies of therapeutic drugs before approval by regulatory agencies. Analyses of drugs after approval can therefore improve our understanding of their mechanism of action and enable better therapies. We screened a library of 1443 Food and Drug Administration (FDA)-approved drugs using a simple assay in the nematode C. elegans and found three compounds that caused morphological changes. While the anticoagulant ticlopidine and the antifungal sertaconazole caused both accumulations that resulted in distinct distortions of pharyngeal anatomy and lethality upon acute exposure, the proton-pump inhibitor dexlansoprazole caused molting defects and required exposure during larval development. Such easily detectable defects in a powerful genetic model system advocate the continued exploration of current medicines using a variety of model organisms to better understand drugs already prescribed to millions of patients.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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