Regulation of cancer cell glucose metabolism is determinant for cancer cell fate after melatonin administration.

Autor:	Rodríguez C; Department of Morphology and Cell Biology, Faculty of Medicine, University of Oviedo, Oviedo, Spain.; University Institute of Oncology of the Principality of Asturias (IUOPA), University of Oviedo, Oviedo, Spain.; Health Research Institute of the Principality of Asturias (ISPA), University of Oviedo, Oviedo, Spain., Puente-Moncada N; Department of Morphology and Cell Biology, Faculty of Medicine, University of Oviedo, Oviedo, Spain.; University Institute of Oncology of the Principality of Asturias (IUOPA), University of Oviedo, Oviedo, Spain.; Health Research Institute of the Principality of Asturias (ISPA), University of Oviedo, Oviedo, Spain., Reiter RJ; Department of Cell Systems and Anatomy, University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, Texas., Sánchez-Sánchez AM; Department of Morphology and Cell Biology, Faculty of Medicine, University of Oviedo, Oviedo, Spain.; University Institute of Oncology of the Principality of Asturias (IUOPA), University of Oviedo, Oviedo, Spain.; Health Research Institute of the Principality of Asturias (ISPA), University of Oviedo, Oviedo, Spain., Herrera F; Cell Structure and Dynamics Laboratory, Institute of Chemical and Biological Technology (ITQB-NOVA), Estação Agronómica Nacional, Oeiras, Portugal., Rodríguez-Blanco J; Molecular Oncology Program, Department of Surgery, The DeWitt Daughtry Family, Miller School of Medicine, University of Miami, Miami, Florida.; Department of Pediatrics, Darby Children's Research Institute, Medical University of South Carolina, Charleston, South Carolina.; Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina., Duarte-Olivenza C; Department of Morphology and Cell Biology, Faculty of Medicine, University of Oviedo, Oviedo, Spain.; University Institute of Oncology of the Principality of Asturias (IUOPA), University of Oviedo, Oviedo, Spain.; Health Research Institute of the Principality of Asturias (ISPA), University of Oviedo, Oviedo, Spain., Turos-Cabal M; Department of Morphology and Cell Biology, Faculty of Medicine, University of Oviedo, Oviedo, Spain.; University Institute of Oncology of the Principality of Asturias (IUOPA), University of Oviedo, Oviedo, Spain.; Health Research Institute of the Principality of Asturias (ISPA), University of Oviedo, Oviedo, Spain., Antolín I; Department of Morphology and Cell Biology, Faculty of Medicine, University of Oviedo, Oviedo, Spain.; University Institute of Oncology of the Principality of Asturias (IUOPA), University of Oviedo, Oviedo, Spain.; Health Research Institute of the Principality of Asturias (ISPA), University of Oviedo, Oviedo, Spain., Martín V; Department of Morphology and Cell Biology, Faculty of Medicine, University of Oviedo, Oviedo, Spain.; University Institute of Oncology of the Principality of Asturias (IUOPA), University of Oviedo, Oviedo, Spain.; Health Research Institute of the Principality of Asturias (ISPA), University of Oviedo, Oviedo, Spain.
Jazyk:	angličtina
Zdroj:	Journal of cellular physiology [J Cell Physiol] 2021 Jan; Vol. 236 (1), pp. 27-40. Date of Electronic Publication: 2020 Jul 29.
DOI:	10.1002/jcp.29886
Abstrakt:	Several oncogenic pathways plus local microenvironmental conditions, such as hypoxia, converge on the regulation of cancer cells metabolism. The major metabolic alteration consists of a shift from oxidative phosphorylation as the major glucose consumer to aerobic glycolysis, although most of cancer cells utilize both pathways to a greater or lesser extent. Aerobic glycolysis, together with the directly related metabolic pathways such as the tricarboxylic acid cycle, the pentose phosphate pathway, or gluconeogenesis are currently considered as therapeutic targets in cancer research. Melatonin has been reported to present numerous antitumor effects, which result in a reduced cell growth. This is achieved with both low and high concentrations with no relevant side effects. Indeed, high concentrations of this indolamine reduce proliferation of cancer types resistant to low concentrations and induce cell death in some types of tumors. Previous work suggest that regulation of glucose metabolism and other related pathways play an important role in the antitumoral effects of high concentration of melatonin. In the present review, we analyze recent work on the regulation by such concentrations of this indolamine on aerobic glycolysis, gluconeogenesis, the tricarboxylic acid cycle and the pentose phosphate pathways of cancer cells. (© 2020 Wiley Periodicals LLC.)
Databáze:	MEDLINE
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