INSIGHTS ON AROMATASE IMMUNOHISTOCHEMISTRY: VARIATIONS BETWEEN INTRINSIC MOLECULAR SUBTYPES OF BREAST CANCERS.

Autor: Armasu I; 'Gr. T. Popa' University of Medicine and Pharmacy - Physiology, Iasi, Romania., Preda C; 'Gr. T. Popa' University of Medicine and Pharmacy - Endocrinology, Iasi, Romania., Ianole V; 'Gr. T. Popa' University of Medicine and Pharmacy - Pathology, Iasi, Romania., Mocanu V; 'Gr. T. Popa' University of Medicine and Pharmacy - Pathophysiology, Iasi, Romania., Hristov I; 'Gr. T. Popa' University of Medicine and Pharmacy - Pathophysiology, Iasi, Romania., Andriescu EC; 'Gr. T. Popa' University of Medicine and Pharmacy - Pathology, Iasi, Romania., Cretu-Silivestru I; 'Gr. T. Popa' University of Medicine and Pharmacy - Pathophysiology, Iasi, Romania., Vasiliu I; 'Gr. T. Popa' University of Medicine and Pharmacy - Physiology, Iasi, Romania., Dascalu CG; 'Gr. T. Popa' University of Medicine and Pharmacy - Medical Informatics and Biostatistics, General Surgery, Iasi, Romania., Lupascu CD; 'Gr. T. Popa' University of Medicine and Pharmacy - Medical Informatics and Biostatistics, General Surgery, Iasi, Romania., Crumpei I; 'Gr. T. Popa' University of Medicine and Pharmacy - Medical Informatics and Biostatistics, General Surgery, Iasi, Romania., Serban DN; 'Gr. T. Popa' University of Medicine and Pharmacy - Physiology, Iasi, Romania., Serban IL; 'Gr. T. Popa' University of Medicine and Pharmacy - Physiology, Iasi, Romania., Ciobanu Apostol DG; 'Gr. T. Popa' University of Medicine and Pharmacy - Pathology, Iasi, Romania.
Jazyk: angličtina
Zdroj: Acta endocrinologica (Bucharest, Romania : 2005) [Acta Endocrinol (Buchar)] 2020 Jan-Mar; Vol. 16 (1), pp. 22-29.
DOI: 10.4183/aeb.2020.22
Abstrakt: Context: Aromatase is a key enzyme in local estrogen production by androgen conversion, especially in women post-menopause. There have been controversies concerning aromatase localization in breast carcinomas and its association with current histopathological variables.
Material and Methods: Using polyclonal antibody immunohistochemistry we assessed (by intensity and percentage scores) the immunolocalization of aromatase in 70 tissue samples, and described particularities within the molecular subtypes of breast cancer.
Results: Aromatase was found in all tissue compartments: tumor (95.7%), stroma (58.6%) and adipose tissue (94.3%). Aromatase expression in tumor cells correlated inversely with tumor grading (p=-0.361, p=0.027), and positively with estrogen receptor status (ER, p=0.143, p<0.001). Dividing the study group by intrinsic subtypes, a strongly inversely association between tumor aromatase and grading (p=-0.486, p<0.001), and between stromal aromatase and Ki67-index (p=-0.448, p=0.048) was observed in luminal A breast cancer. Tumor aromatase and ER percentage scores had stronger correlations in luminal B HER2 negative (p=0.632, p=0.002), and positive (p=0.324, p=0.026) tumors. In contrast, in triple negative tumors, a positive association stromal aromatase and Ki67 index (p=-0.359, p=0.007) was observed.
Conclusion: Local aromatase was linked to better tumor differentiation and proliferation in luminal breast subtypes, and not in triple negative cases, suggesting a potential prognostic role of aromatase in breast carcinomas.
(©by Acta Endocrinologica Foundation.)
Databáze: MEDLINE
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