| Autor: |
Luo SW; State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha, 410081, PR China. swluo@hunnu.edu.cn., Wei W; Key Laboratory of Ecology and Environmental Science in Guangdong Higher Education, Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture, College of Life Science, South China Normal University, Guangzhou, 510631, PR China. |
| Jazyk: |
angličtina |
| Zdroj: |
Ecotoxicology (London, England) [Ecotoxicology] 2020 Sep; Vol. 29 (7), pp. 837-845. Date of Electronic Publication: 2020 Jul 12. |
| DOI: |
10.1007/s10646-020-02252-x |
| Abstrakt: |
Vibrio alginolyticus is posting an increasing threat to survival of grouper. Classical complement cascade can trigger initiation of immunity, while complement 9 (C9) is a major complement molecule involved in final step of membrane attack complex (MAC) formation. In this study, full-length EcC9 contained an ORF sequence of 1779 bp, encoding a polypeptide of 592 amino acids. A high-level expression of EcC9 mRNA was observed in liver. Following vibrio challenge, increased expression levels of EcC1q, EcBf/C2, EcC4, EcC6, EcC7 and EcC9 mRNA were detected in liver and kidney. These results implied that elevated expression level of classical complement pathway (CCP) and terminal complement components (TCCs) may assess toxicological effect of V. alginolyticus. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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