The relationship between DNA methylation in neurotrophic genes and age as evidenced from three independent cohorts: differences by delirium status.

Autor: Saito T; Department of Psychiatry, University of Iowa, Iowa City, IA, USA; Department of Psychiatry, School of Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan., Braun PR; Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Daniel S; Department of Psychiatry, University of Iowa, Iowa City, IA, USA., Jellison SS; Department of Psychiatry, University of Iowa, Iowa City, IA, USA., Hellman M; Department of Psychiatry, University of Iowa, Iowa City, IA, USA., Shinozaki E; Department of Internal Medicine, University of Iowa, Iowa City, IA, USA., Lee S; Department of Emergency Medicine, University of Iowa, Iowa City, IA, USA., Cho HR; Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA, USA., Yoshino A; Department of Psychiatry, School of Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan., Toda H; Department of Psychiatry, School of Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan., Shinozaki G; Department of Psychiatry, University of Iowa, Iowa City, IA, USA; Department of Neurosurgery, University of Iowa, Iowa City, IA, USA; Department of Anesthesia, Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA; Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA, USA. Electronic address: gen-shinozaki@uiowa.edu.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2020 Oct; Vol. 94, pp. 227-235. Date of Electronic Publication: 2020 Jun 12.
DOI: 10.1016/j.neurobiolaging.2020.06.003
Abstrakt: We previously reported the association between DNA methylation (DNAm) of pro-inflammatory cytokine genes and age. In addition, neurotrophic factors are known to be associated with age and neurocognitive disorders. Therefore, we hypothesized that DNAm of neurotrophic genes change with age, especially in delirium patients. DNAm was analyzed using the Illumina HumanMethylation450 or HumanMethylationEPIC BeadChip Kit in 3 independent cohorts: blood from 383 Grady Trauma Project subjects, brain from 21 neurosurgery patients, and blood from 87 inpatients with and without delirium. Both blood and brain samples showed that most of the DNAm of neurotrophic genes were positively correlated with age. Furthermore, DNAm of neurotrophic genes was more positively correlated with age in delirium cases than in non-delirium controls. These findings support our hypothesis that the neurotrophic genes may be epigenetically modulated with age, and this process may be contributing to the pathophysiology of delirium.
(Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: