Ex vivo-expanded autologous adipose tissue-derived stromal cells ensure enhanced fat graft retention in breast augmentation: A randomized controlled clinical trial.

Autor: Kølle ST; Department of Stem Cell Research, Stemform, Copenhagen, Denmark.; Department of Plastic Surgery, Aleris Hamlet Hospitals, Copenhagen, Denmark., Duscher D; Department of Plastic and Hand Surgery, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.; Kepler University Hospital, Johannes Kepler University, Linz, Austria., Taudorf M; Department of Radiology, University Hospital of Copenhagen, Copenhagen, Denmark., Fischer-Nielsen A; Department of Stem Cell Research, Stemform, Copenhagen, Denmark.; Department of Clinical Immunology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark., Svalgaard JD; Department of Stem Cell Research, Stemform, Copenhagen, Denmark.; Department of Clinical Immunology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark., Munthe-Fog L; Department of Stem Cell Research, Stemform, Copenhagen, Denmark., Jønsson B; Department of Stem Cell Research, Stemform, Copenhagen, Denmark.; Department of Plastic Surgery, Aleris Hamlet Hospitals, Copenhagen, Denmark., Selvig PB; Department of Stem Cell Research, Stemform, Copenhagen, Denmark., Mamsen FP; Department of Stem Cell Research, Stemform, Copenhagen, Denmark.; Department of Plastic Surgery, Aleris Hamlet Hospitals, Copenhagen, Denmark., Katz AJ; Department of Plastic and Reconstructive Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Jazyk: angličtina
Zdroj: Stem cells translational medicine [Stem Cells Transl Med] 2020 Nov; Vol. 9 (11), pp. 1277-1286. Date of Electronic Publication: 2020 Jul 08.
DOI: 10.1002/sctm.20-0081
Abstrakt: Autologous fat grafting and implant surgery are used for volume restoration in plastic surgery. With the aim of producing a treatment superior to current solutions, we report a randomized, controlled, data assessor-blinded clinical trial comparing fat grafts enriched with ex vivo-expanded autologous adipose-derived stromal cells (ASCs) to nonenriched fat grafts in breast augmentation. The intervention group received ASC-enriched fat grafts (≥20 × 10 6 viable ex vivo-expanded ASCs per milliliter fat), and the control group received conventional nonenriched fat grafts. Volume retention was measured by magnetic resonance imaging, and clinical photographs were taken simultaneously for outcome evaluation. ASC-enriched fat grafts had significantly higher retention rates (mean = 80.2%) compared with conventional fat grafts (mean = 45.1%). Clinical photos showed statistically significant superior results in the intervention group, assessed by independent clinical experts. These results improve the prospects for using culture-expanded ASCs in both reconstructive and cosmetic volume restoration and make the procedure an attractive alternative to conventional fat grafting and implants. This study is registered at www.ClinicalTrials.gov, number H-16046960.
(© 2020 The Authors. STEM CELLS TRANSLATIONAL MEDICINE published by Wiley Periodicals LLC on behalf of AlphaMed Press.)
Databáze: MEDLINE
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