Introduction of principles of blood management to healthy donor bone marrow harvesting.

Autor: Kim-Wanner SZ; German Red Cross Blood Service Baden-Württemberg-Hessen, Institute Frankfurt, Frankfurt, Germany., Luxembourg B; Department of Hemostaseology, Justus Liebig University, Giessen, Germany., Schmidt AH; DKMS, Tübingen, Germany., Schäfer R; German Red Cross Blood Service Baden-Württemberg-Hessen, Institute Frankfurt, Frankfurt, Germany., Möller N; German Red Cross Blood Service Baden-Württemberg-Hessen, Institute Frankfurt, Frankfurt, Germany., Herbert E; German Red Cross Blood Service Baden-Württemberg-Hessen, Institute Frankfurt, Frankfurt, Germany., Poppe C; German Red Cross Blood Service Baden-Württemberg-Hessen, Institute Frankfurt, Frankfurt, Germany., Hümmer C; German Red Cross Blood Service Baden-Württemberg-Hessen, Institute Frankfurt, Frankfurt, Germany., Bunos M; German Red Cross Blood Service Baden-Württemberg-Hessen, Institute Frankfurt, Frankfurt, Germany., Seifried E; German Red Cross Blood Service Baden-Württemberg-Hessen, Institute Frankfurt, Frankfurt, Germany.; Goethe University, Institute for Transfusion Medicine and Immunohematology, Frankfurt, Germany., Bonig H; German Red Cross Blood Service Baden-Württemberg-Hessen, Institute Frankfurt, Frankfurt, Germany.; Goethe University, Institute for Transfusion Medicine and Immunohematology, Frankfurt, Germany.; Department of Medicine/Hematology, University of Washington, Seattle, WA, USA.
Jazyk: angličtina
Zdroj: Vox sanguinis [Vox Sang] 2020 Nov; Vol. 115 (8), pp. 802-812. Date of Electronic Publication: 2020 Jul 07.
DOI: 10.1111/vox.12972
Abstrakt: Background and Objectives: Patient blood (more accurately: haemoglobin, Hb) management (PBM) aims to optimize endogenous Hb production and to minimize iatrogenic Hb loss while maintaining patient safety and optimal effectiveness of medical interventions. PBM was adopted as policy for patients by the World Health Organization (WHO), and, all the more, should be applied to healthy donors.
Materials and Methods: Observational data from 489 bone marrow (BM) donors were retrospectively analysed, and principles of patient blood management were applied to healthy volunteer BM donations.
Results and Conclusion: We managed to render BM aspiration safe for donors, notably completely avoiding the collection of autologous blood units and blood transfusions through iron management, establishment and curation of high-yield aspiration technique, limitation of collection volume to 1·5% of donor body weight and development of volume prediction algorithms for the requested cell dose.
(© 2020 The Authors. Vox Sanguinis published by John Wiley & Sons Ltd on behalf of International Society of Blood Transfusion.)
Databáze: MEDLINE
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