Breastfeeding and Formula Selection in Neonatal Abstinence Syndrome.

Autor:	Lembeck AL; Division of Neonatology, Department of Pediatrics, Einstein Medical Center Montgomery, CHOP Newborn Care Network, East Norriton, Pennsylvania., Tuttle D; Department of Pediatrics, Christiana Care Health System, Newark, Delaware.; Sidney Kimmel School of Medicine at Thomas Jefferson University, Philadelphia, Pennsylvania., Locke R; Department of Pediatrics, Christiana Care Health System, Newark, Delaware.; Sidney Kimmel School of Medicine at Thomas Jefferson University, Philadelphia, Pennsylvania., Lawler L; Department of Pediatrics, Christiana Care Health System, Newark, Delaware., Jimenez P; Department of Pediatrics, Christiana Care Health System, Newark, Delaware., Mackley A; Department of Pediatrics, Christiana Care Health System, Newark, Delaware., Paul DA; Department of Pediatrics, Christiana Care Health System, Newark, Delaware.; Sidney Kimmel School of Medicine at Thomas Jefferson University, Philadelphia, Pennsylvania.
Jazyk:	angličtina
Zdroj:	American journal of perinatology [Am J Perinatol] 2021 Dec; Vol. 38 (14), pp. 1488-1493. Date of Electronic Publication: 2020 Jun 30.
DOI:	10.1055/s-0040-1713754
Abstrakt:	Objective: This study aimed to determine if formula selection, low lactose versus standard term formula, has an effect on outcomes with a comparison to breastfed infants. Study Design: Retrospective cohort study of neonates ≥35 weeks gestation born with Neonatal Abstinence Syndrome (NAS) was conducted from July 2014 to November 2016. Primary outcomes included length of pharmacologic treatment (LOT), and length of stay (LOS), and weight change per day comparing term standard and low lactose formula majority feeding infants with secondary outcomes comparing breast fed majority feeding infants. Results: After investigating feeding methods for 249 NAS infants, a direct comparison of formula groups showed no differences in LOS (3, 95% confidence interval [CI]: -1.1 to 7 days), LOT (3.9, 95% CI: -0.4 to 8.1 days), or weight change per day (-2.4, 95% CI: -11.7 to 6.9 g/day). Breastfeeding improved LOT by 6.9 (95% CI: 3.4-10.5) and 10.8 days (95% CI: 5.9-15.6) and LOS by 7.4 (95% CI: 4.1-10.7) and 10.3 (95% CI: 5.8-14.9) days all reaching significance, in comparison to term and low lactose formula groups, respectively. Weight change per day was greater in the breast versus formula feeding groups when compared individually. Conclusion: We detected no benefit to low lactose formula in NAS infants. Breastfeeding is associated with clinical reduction in LOS and LOT but is associated with increased weight loss. Key Points: · Best formula choice for a neonatal abstinence syndrome (NAS) infant is unknown.. · Many NAS moms cannot breastfeed.. · Low lactose formula has no impact on NAS outcomes.. Competing Interests: None declared. (Thieme. All rights reserved.)
Databáze:	MEDLINE
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