| Autor: |
Kharlamovа OS; Research Institute of Therapy and Preventive Medicine - branch of the Federal Research Center Institute of Cytology and Genetics.; City Clinical Hospital №25., Nikolaev KY; Research Institute of Therapy and Preventive Medicine - branch of the Federal Research Center Institute of Cytology and Genetics.; Novosibirsk National Research State University., Ragino YI; Research Institute of Therapy and Preventive Medicine - branch of the Federal Research Center Institute of Cytology and Genetics., Voevoda MI; Research Institute of Therapy and Preventive Medicine - branch of the Federal Research Center Institute of Cytology and Genetics. |
| Jazyk: |
ruština |
| Zdroj: |
Terapevticheskii arkhiv [Ter Arkh] 2020 Apr 27; Vol. 92 (3), pp. 109-115. Date of Electronic Publication: 2020 Apr 27. |
| DOI: |
10.26442/00403660.2020.03.000275 |
| Abstrakt: |
Community-acquired pneumonia is one of the most common infectious diseases and remains one of the leading causes of death in this group of diseases. Studies of community-acquired pneumonia are extremely relevant for modern clinical practice. One of the important role in the pathogenesis of bacterial, viral, fungal invasion in the system of a human lung system belongs to the pulmonary surfactant, in particular, its proteins SP-A and SP-D. This article reviews the well-known mechanisms of important biological properties of immunomodulatory activity of the proteins SP-A and SP-D in response to microbial infection in the lungs. The mechanisms of participation of surfactant proteins SP-A and SP-D in the cascade of reactions that lead to severe life-threatening complications in community-acquired pneumonia are considered. The use of serum levels of surfactant proteins SP-A and SP-D can help finding new diagnostic and prognostic approaches in patients with community-acquired pneumonia. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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