Facial nerve repair utilizing intraoperative repair strategies.

Autor: Brown BL; Department of Anatomy, Cell Biology and Physiology Indiana University School of Medicine Indianapolis Indiana USA.; Department of Anatomical Sciences and Neurobiology University of Louisville Louisville Kentucky USA., Sandelski MM; Department of Anatomy, Cell Biology and Physiology Indiana University School of Medicine Indianapolis Indiana USA., Drejet SM; Department of Otolaryngology Indiana University School of Medicine Indianapolis Indiana USA., Runge EM; Department of Anatomy, Cell Biology and Physiology Indiana University School of Medicine Indianapolis Indiana USA., Shipchandler TZ; Department of Otolaryngology Indiana University School of Medicine Indianapolis Indiana USA., Jones KJ; Department of Anatomy, Cell Biology and Physiology Indiana University School of Medicine Indianapolis Indiana USA.; Research and Development Service Richard L Roudebush Veterans Affairs Medical Center Indianapolis Indiana USA., Walker CL; Department of Anatomy, Cell Biology and Physiology Indiana University School of Medicine Indianapolis Indiana USA.; Research and Development Service Richard L Roudebush Veterans Affairs Medical Center Indianapolis Indiana USA.; Department of Biomedical Sciences and Comprehensive Care Indiana University School of Dentistry Indianapolis Indiana USA.
Jazyk: angličtina
Zdroj: Laryngoscope investigative otolaryngology [Laryngoscope Investig Otolaryngol] 2020 May 28; Vol. 5 (3), pp. 552-559. Date of Electronic Publication: 2020 May 28 (Print Publication: 2020).
DOI: 10.1002/lio2.411
Abstrakt: Objectives: To determine whether functional and anatomical outcomes following suture neurorrhaphy are improved by the addition of electrical stimulation with or without the addition of polyethylene glycol (PEG).
Methods: In a rat model of facial nerve injury, complete facial nerve transection and repair was performed via (a) suture neurorrhaphy alone, (b) neurorrhaphy with the addition of brief (30 minutes) intraoperative electrical stimulation, or (c) neurorrhaphy with the addition electrical stimulation and PEG. Functional recovery was assessed weekly for 16 weeks. At 16 weeks postoperatively, motoneuron survival, amount of regrowth, and specificity of regrowth were assessed by branch labeling and tissue analysis.
Results: The addition of brief intraoperative electrical stimulation improved all functional outcomes compared to suturing alone. The addition of PEG to electrical stimulation impaired this benefit. Motoneuron survival, amount of regrowth, and specificity of regrowth were unaltered at 16 weeks postoperative in all treatment groups.
Conclusion: The addition of brief intraoperative electrical stimulation to neurorrhaphy in this rodent model shows promising neurological benefit in the surgical repair of facial nerve injury.
Level of Evidence: Animal study.
Competing Interests: The authors declare no potential conflict of interest.
(© 2020 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals, Inc. on behalf of The Triological Society.)
Databáze: MEDLINE
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