Treatment and outcome in 12 cases of olfactory neuroblastoma at Mexico´s National Cancer Institute: A retrospective clinical analysis and literature review.

Autor:	Navarro-Fernández JO; Department of Head and Neck, Unidad de Neurociencias, Instituto Nacional de Cancerología. Ciudad de México, Mexico., Serrato-Avila JL; Department of Neurosurgery, Centro Médico Nacional 20 de Noviembre, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado. Ciudad de México, Mexico., Hernández-Varela M; School of Medicine. Santiago Ramón y Cajal, Universidad Westhill. Ciudad de México, Mexico., Tejada-Pineda MF; School of Medicine Ignacio Santos, Instituto Tecnológico de Estudios Superiores de Monterrey, Campus Ciudad de México. Ciudad de México, Mexico., Hernández-Reséndiz RE; Hospital Central Sur de Alta Especialidad, Petróleos Mexicanos. Ciudad de México, Mexico., Monroy-Sosa A; Department of Head and Neck, Unidad de Neurociencias, Instituto Nacional de Cancerología. Ciudad de México, Mexico., Cacho-Díaz B; Department of Head and Neck, Unidad de Neurociencias, Instituto Nacional de Cancerología. Ciudad de México, Mexico., Herrera-Gómez Á; Department of Oncological Surgery, Instituto Nacional de Cancerología. Ciudad de México, Mexico., Reyes-Soto G; Department of Head and Neck, Unidad de Neurociencias, Instituto Nacional de Cancerología. Ciudad de México, Mexico.
Jazyk:	angličtina
Zdroj:	Cirugia y cirujanos [Cir Cir] 2020; Vol. 88 (4), pp. 453-460.
DOI:	10.24875/CIRU.19001111
Abstrakt:	Introduction: Olfactory neuroblastoma (ONB) is a malignant neoplasm that arises from the upper nasal vault. Objective: We present a retrospective case series and clinical analysis of 12 ONB cases. Materials and Methods: Patients with ONB treated at Mexico´s National Cancer Institute between 2011 and 2018. Results: The Kadish proportion of B, C, and D stage was 16%, 58%, or 25%, respectively. Hyams Grade 1, 2, or 3 was 25%, 50%, and 25%, respectively. The most common surgical approach was the craniofacial in 5 cases (42%), followed by the transfacial in 4 cases (33%), and the endonasal endoscopic approach in 3 cases (25%). Gross total resection was achieved in 8 patients (67%). Five patients (42%) underwent a second operation due to recurrent/progressive disease. The surgical complication rate was 8.3%. Progression-free survival was 41 months and the mean overall survival was 63.6 months. Conclusions: Surgical resection followed by radiotherapy, and chemotherapy for metastatic and recurrent disease provides the best outcome in terms of survival and recurrence. To the best of our knowledge, this is the first series of cases reported in Mexico. (Copyright: © 2020 Permanyer.)
Databáze:	MEDLINE
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