Palatal needle-free anesthesia for upper molars extraction. A randomized clinical trial.

Autor: Amorim KS; Pharmacology, Anesthesiology and Therapeutics Department of the Piracicaba Dental School, University of Campinas, 901 Limeira Avenue, 13414-903, Piracibaba, São Paulo, Brazil. Electronic address: klinger.amorim@outlook.com., Franz-Montan M; Pharmacology, Anesthesiology and Therapeutics Department of the Piracicaba Dental School, University of Campinas, 901 Limeira Avenue, 13414-903, Piracibaba, São Paulo, Brazil., Groppo FC; Pharmacology, Anesthesiology and Therapeutics Department of the Piracicaba Dental School, University of Campinas, 901 Limeira Avenue, 13414-903, Piracibaba, São Paulo, Brazil., Muniz BV; Pharmacology, Anesthesiology and Therapeutics Department of the Piracicaba Dental School, University of Campinas, 901 Limeira Avenue, 13414-903, Piracibaba, São Paulo, Brazil., Araújo JSM; Pharmacology, Anesthesiology and Therapeutics Department of the Piracicaba Dental School, University of Campinas, 901 Limeira Avenue, 13414-903, Piracibaba, São Paulo, Brazil., Santana JVF; Federal University of Sergipe, Oral Surgery and Anesthesiology Area of Dentistry Department, St Cláudio Batista, 49060-108, Aracaju, Cidade Nova, Sergipe, Brazil., Dantas ACGC; Federal University of Sergipe, Oral Surgery and Anesthesiology Area of Dentistry Department, St Cláudio Batista, 49060-108, Aracaju, Cidade Nova, Sergipe, Brazil., de Paula E; Biochemistry and Tissue Biology Department, Biology Institute, University of Campinas, St Monteiro Lobato 255, 13083-862, Campinas, São Paulo, Brazil., Souza LMA; Federal University of Sergipe, Oral Surgery and Anesthesiology Area of Dentistry Department, St Cláudio Batista, 49060-108, Aracaju, Cidade Nova, Sergipe, Brazil.
Jazyk: angličtina
Zdroj: Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery [J Craniomaxillofac Surg] 2020 Aug; Vol. 48 (8), pp. 815-819. Date of Electronic Publication: 2020 May 11.
DOI: 10.1016/j.jcms.2020.05.001
Abstrakt: Background: The aim of this study was to compare the ability of liposomal and non-liposomal lidocaine and prilocaine in hydrogel formulations to promote topical anesthesia in palatal mucosa during upper molar extractions.
Methods: In this randomized, cross over, triple-blinded clinical trial, a liposomal and a non-liposomal formulation of the eutectic mixture of local anesthetics, 2.5% lidocaine and 2.5% prilocaine, were used to promote palatal anesthesia without the local anesthetic infiltration during bilateral upper molars extractions.
Results: From the total of 40 patients included in this study, the non-liposomal eutectic lidocaine-prilocaine formulation failed in 40% of cases, unlike the liposomal formulation, which was effective for all patients (Fisher's exact test, p < 0.0001). Furthermore, the liposomal formulation (26.75 ± 7,47 min) induced longer anesthesia duration (t-test, p < 0.0001) than the non-liposomal formulation (16.78 ± 4.75 min). No mucosal ulceration or discomfort was reported for both formulations.
Conclusion: The liposomal formulation was able to induce adequate anesthesia in palatal mucosa during dental extraction, avoiding the local anesthetic infiltration. For the first time, a topical formulation allowed upper molars surgical removal without injection of any local anesthetic agent into palatal mucosa in adults.
(Copyright © 2020 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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