Subacute toxicity assessment of biobased ionic liquids in rats.

Autor: Toledo Hijo AAC; Laboratory of Extraction, Applied Thermodynamics and Equilibrium (EXTRAE), School of Food Engineering, University of Campinas, R. Monteiro Lobato 80, 13083-862 Campinas, São Paulo, Brazil., Barros HDFQ; Laboratory of Biological Assays (LEB), School of Food Engineering, University of Campinas, R. Monteiro Lobato 80, 13083-862 Campinas, São Paulo, Brazil., Maximo GJ; Laboratory of Extraction, Applied Thermodynamics and Equilibrium (EXTRAE), School of Food Engineering, University of Campinas, R. Monteiro Lobato 80, 13083-862 Campinas, São Paulo, Brazil., Cazarin CBB; Laboratory of Biological Assays (LEB), School of Food Engineering, University of Campinas, R. Monteiro Lobato 80, 13083-862 Campinas, São Paulo, Brazil., da Costa LBE; School of Medical Sciences, University of Campinas, R. Tessália Vieira de Camargo, 126, 13083-887 Campinas, São Paulo, Brazil., Pereira JFB; School of Pharmaceutical Sciences, Universidade Estadual Paulista, 14800-903, Araraquara, São Paulo, Brazil., Maróstica Junior MR; Laboratory of Biological Assays (LEB), School of Food Engineering, University of Campinas, R. Monteiro Lobato 80, 13083-862 Campinas, São Paulo, Brazil., Meirelles AJA; Laboratory of Extraction, Applied Thermodynamics and Equilibrium (EXTRAE), School of Food Engineering, University of Campinas, R. Monteiro Lobato 80, 13083-862 Campinas, São Paulo, Brazil. Electronic address: tomze@unicamp.br.
Jazyk: angličtina
Zdroj: Food research international (Ottawa, Ont.) [Food Res Int] 2020 Aug; Vol. 134, pp. 109125. Date of Electronic Publication: 2020 Feb 24.
DOI: 10.1016/j.foodres.2020.109125
Abstrakt: Ionic liquids (ILs) derived from compounds obtained from natural sources, such as fatty acids (FAs) have attracted the interest of the scientific and industrial communities because of their sustainable appeal and possible low toxic effects or nontoxicity. These aspects open new perspective of applications in other fields, which demands a better comprehension of their toxicity. This work evaluated the subacute toxicity of bis(2-hydroxyethyl)ammonium carboxylates in Wistar rats, considering the alkyl chain length of FAs (capric and oleic acids), and the concentration (0.16%, 1.6% or 3.2%, w IL /w Oil ) of ILs added in diets. The blood serum of the rats was evaluated in relation to total cholesterol, triglycerides, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and γ-glutamyl transferase. Lipid peroxidation was determined in plasma, liver and kidney tissues by determining the level of thiobarbituric acid reactive substances. Histological analyses of the liver and kidney tissues were performed in order to evaluate morphological changes. No signal of toxicity was observed according to lipid peroxidation. Triglycerides increased with the increasing of the concentration and alkyl chain length of the IL, but no difference in serum level of lipid peroxidation was observed. This behavior may be attributed to the amphiphilic nature of FAs based ILs, which might facilitate lipid digestion. However, more studies are necessary in order to understand such behavior. Therefore, the synthesis of ILs from FAs, has been evaluated as a strategy to produce compounds with low or without toxicity for the agro-food, pharmaceutical or cosmetic industries.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020. Published by Elsevier Ltd.)
Databáze: MEDLINE
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