| Autor: |
Okunlola A; Department of Pharmaceutics and Industrial Pharmacy, University of Ibadan, Ibadan, Nigeria., Odeniyi MA; Department of Pharmaceutics and Industrial Pharmacy, University of Ibadan, Ibadan, Nigeria., Arhewoh MI; Department of Pharmaceutics and Pharmaceutical Technology, University of Benin, Benin City, Nigeria. arhewoh@uniben.edu. |
| Jazyk: |
angličtina |
| Zdroj: |
Progress in biomaterials [Prog Biomater] 2020 Jun; Vol. 9 (1-2), pp. 65-80. Date of Electronic Publication: 2020 Jun 05. |
| DOI: |
10.1007/s40204-020-00132-5 |
| Abstrakt: |
Ambroxol hydrochloride (AH), a secretion-releasing expectorant, is a good candidate for sustained delivery. Mucilages are biodegradable, inexpensive carriers in microsphere formulations. The study aimed to prepare microspheres of AH using Okra mucilage obtained from pods of Abelmoschus esculentus combined with sodium alginate at various polymer/drug ratios. Okra mucilage was characterized for morphology, swelling, viscosity and flow properties. AH microspheres were prepared by ionic emulsification method and characterized using size, entrapment efficiency, swelling index and dissolution time (t 50 ). A full 2 by 3 factorial experimental design using three factors (Okra mucilage/alginate ratio X 1 ; drug/polymer ratio X 2 ; and polymer concentration X 3 ), each at two levels, was used to determine the effects of formulation variables on the responses. Optimized formulations of AH microspheres had sizes ranging from 250.91 ± 16.22 to 462.10 ± 23.85 µm; swelling index 1.35 ± 0.05 and 3.20 ± 0.03 and entrapment 55.70 ± 3.55-94.11 ± 4.50%. The microspheres exhibited sustained release of AH over a prolonged period as revealed by the dissolution time (t 50 ) 2.85 ± 1.03-7.50 ± 0.96 h. Drug release kinetics generally followed zero order, implying that the process is constant and independent of the initial concentration of drug. Polymer concentration had the highest influence on microsphere size, entrapment efficiency and dissolution time while Okra/alginate ratio had the highest influence on swelling. Okra mucilage was a suitable polymer that could serve as an alternative to synthetic polymers in sustaining the release of ambroxol hydrochloride. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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