| Autor: |
Kapilevich LV; National Research Tomsk State University, Tomsk, Russia. kapil@yandex.ru.; National Research Tomsk Polytechnic University, Tomsk, Russia. kapil@yandex.ru.; Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia. kapil@yandex.ru., Milovanova KG; National Research Tomsk State University, Tomsk, Russia., Sidorenko SV; National Research Tomsk State University, Tomsk, Russia.; M. V. Lomonosov Moscow State University, Moscow, Russia., Fedorov DA; National Research Tomsk State University, Tomsk, Russia.; M. V. Lomonosov Moscow State University, Moscow, Russia., Kironenko TA; National Research Tomsk State University, Tomsk, Russia., Zakharova AN; National Research Tomsk State University, Tomsk, Russia., D'yakova EY; National Research Tomsk State University, Tomsk, Russia., Orlov NS; National Research Tomsk State University, Tomsk, Russia.; M. V. Lomonosov Moscow State University, Moscow, Russia.; Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia. |
| Abstrakt: |
The effects of dynamic and static load on the intracellular concentrations of sodium [Formula: see text] and potassium (K + i ) in m. soleus and m. biceps, respectively, were studied in mice. Both dynamic (swimming for 60 min) and static (hanging on the grid for 40 min) load led to a 2-fold increase in [Formula: see text] level, a decrease in K + i concentration by 25-35%, and 3-4-fold increase in the [Formula: see text] ratio. These effects of dynamic and static loads on the studied parameters remained unchanged in mice subjected to regular physical exercise (swimming or hanging on the grid for 1 h a day over 4 weeks). Our results suggest that dissipation of sodium and potassium transmembrane gradients during physical exercise can be considered as a factor of regulation of functional activity of skeletal muscles, which includes changes in transcription and translation of myokines observed previously. |
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