Trajectory-modulated hippocampal neurons persist throughout memory-guided navigation.

Autor:	Kinsky NR; Center for Systems Neuroscience, Boston University, 610 Commonwealth Ave, 7th Floor, Boston, MA, 02215, USA. nkinsky@gmail.com.; Department of Anesthesiology, University of Michigan, 1301 Catherine St. Rm 7433, Ann Arbor, MI, 48109, USA. nkinsky@gmail.com., Mau W; Center for Systems Neuroscience, Boston University, 610 Commonwealth Ave, 7th Floor, Boston, MA, 02215, USA.; Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, 10th Floor, New York, NY, 10029, USA., Sullivan DW; Center for Systems Neuroscience, Boston University, 610 Commonwealth Ave, 7th Floor, Boston, MA, 02215, USA., Levy SJ; Center for Systems Neuroscience, Boston University, 610 Commonwealth Ave, 7th Floor, Boston, MA, 02215, USA.; Graduate Program for Neuroscience, Boston University, Boston, MA, USA., Ruesch EA; Center for Systems Neuroscience, Boston University, 610 Commonwealth Ave, 7th Floor, Boston, MA, 02215, USA., Hasselmo ME; Center for Systems Neuroscience, Boston University, 610 Commonwealth Ave, 7th Floor, Boston, MA, 02215, USA. hasselmo@bu.edu.
Jazyk:	angličtina
Zdroj:	Nature communications [Nat Commun] 2020 May 15; Vol. 11 (1), pp. 2443. Date of Electronic Publication: 2020 May 15.
DOI:	10.1038/s41467-020-16226-4
Abstrakt:	Trajectory-dependent splitter neurons in the hippocampus encode information about a rodent's prior trajectory during performance of a continuous alternation task. As such, they provide valuable information for supporting memory-guided behavior. Here, we employed single-photon calcium imaging in freely moving mice to investigate the emergence and fate of trajectory-dependent activity through learning and mastery of a continuous spatial alternation task. In agreement with others, the quality of trajectory-dependent information in hippocampal neurons correlated with task performance. We thus hypothesized that, due to their utility, splitter neurons would exhibit heightened stability. We find that splitter neurons were more likely to remain active and retained more consistent spatial information across multiple days than other neurons. Furthermore, we find that both splitter neurons and place cells emerged rapidly and maintained stable trajectory-dependent/spatial activity thereafter. Our results suggest that neurons with useful functional coding exhibit heightened stability to support memory guided behavior.
Databáze:	MEDLINE
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