Bioresorbable Polymeric Scaffold in Cardiovascular Applications.

Autor: Toong DWY; School of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, Singapore 639798, Singapore., Toh HW; National Heart Centre Singapore, 5 Hospital Drive, Singapore 169609, Singapore.; Department of Biomedical Engineering, 4 Engineering Drive 3, Singapore 117583, Singapore., Ng JCK; National Heart Centre Singapore, 5 Hospital Drive, Singapore 169609, Singapore.; Department of Biomedical Engineering, 4 Engineering Drive 3, Singapore 117583, Singapore., Wong PEH; National Heart Centre Singapore, 5 Hospital Drive, Singapore 169609, Singapore.; Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore., Leo HL; Department of Biomedical Engineering, 4 Engineering Drive 3, Singapore 117583, Singapore., Venkatraman S; Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117575, Singapore., Tan LP; School of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, Singapore 639798, Singapore., Ang HY; National Heart Centre Singapore, 5 Hospital Drive, Singapore 169609, Singapore.; Department of Biomedical Engineering, 4 Engineering Drive 3, Singapore 117583, Singapore., Huang Y; School of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, Singapore 639798, Singapore.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2020 May 13; Vol. 21 (10). Date of Electronic Publication: 2020 May 13.
DOI: 10.3390/ijms21103444
Abstrakt: Advances in material science and innovative medical technologies have allowed the development of less invasive interventional procedures for deploying implant devices, including scaffolds for cardiac tissue engineering. Biodegradable materials (e.g., resorbable polymers) are employed in devices that are only needed for a transient period. In the case of coronary stents, the device is only required for 6-8 months before positive remodelling takes place. Hence, biodegradable polymeric stents have been considered to promote this positive remodelling and eliminate the issue of permanent caging of the vessel. In tissue engineering, the role of the scaffold is to support favourable cell-scaffold interaction to stimulate formation of functional tissue. The ideal outcome is for the cells to produce their own extracellular matrix over time and eventually replace the implanted scaffold or tissue engineered construct. Synthetic biodegradable polymers are the favoured candidates as scaffolds, because their degradation rates can be manipulated over a broad time scale, and they may be functionalised easily. This review presents an overview of coronary heart disease, the limitations of current interventions and how biomaterials can be used to potentially circumvent these shortcomings in bioresorbable stents, vascular grafts and cardiac patches. The material specifications, type of polymers used, current progress and future challenges for each application will be discussed in this manuscript.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
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