Outcome comparison between radiation therapy and surgery as primary treatment for dogs with periarticular histiocytic sarcoma: An Italian Society of Veterinary Oncology study.

Autor: Marconato L; Department of Veterinary Medical Sciences, University of Bologna, BO, Italy., Sabattini S; Department of Veterinary Medical Sciences, University of Bologna, BO, Italy., Buchholz J; Small Animal Clinic Hofheim, Hofheim, Germany., Polton G; North Downs Specialist Referrals, Surrey, UK., Finotello R; Department of Small Animal Clinical Science, Institute of Veterinary Science, University of Liverpool, Neston, UK., Martano M; Department of Veterinary Medical Sciences, University of Parma, Parma, Italy., Willman M; Division of Small Animal Internal Medicine, Department of Companion Animals and Horses, University of Veterinary Medicine of Vienna, Vienna, Austria., Massari F; Clinica Veterinaria Nervianese, Nerviano, MI, Italy., Agnoli C; Department of Veterinary Medical Sciences, University of Bologna, BO, Italy., Gedon J; Small Animal Clinic Hofheim, Hofheim, Germany., Cancedda S; Centro Oncologico Veterinario, Sasso Marconi, BO, Italy., Campigli M; Oncology Division, San Marco Veterinary Clinic and Laboratory, Veggiano, PD, Italy., Rohrer Bley C; Division of Radiation Oncology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Jazyk: angličtina
Zdroj: Veterinary and comparative oncology [Vet Comp Oncol] 2020 Dec; Vol. 18 (4), pp. 778-786. Date of Electronic Publication: 2020 Jun 01.
DOI: 10.1111/vco.12609
Abstrakt: Localized histiocytic sarcoma may occur as a primary lesion in periarticular tissues of large appendicular joints. Treatment options for the primary lesion include radical surgical excision, radiation therapy (RT), or both, in combination with chemotherapy for potential systemic metastases. In an effort to better characterize the time to progression (TTP) following surgical vs non-surgical approaches for periarticular histiocytic sarcoma (PAHS), a contemporary European population of affected dogs was retrospectively surveyed. Medical records were queried for newly-diagnosed PAHS cases undergoing surgery (predominantly limb amputation) or RT followed by systemic chemotherapy. Of 49 dogs, 34 underwent RT and 15 underwent surgery. All dogs received adjuvant chemotherapy. There was no statistically significant difference in TTP or overall survival between groups. The median TTP was 336 days for the operated dogs and 217 days for the irradiated dogs (P = .117). The median overall survival time was 398 days for the operated dogs and 240 days for the irradiated dogs (P = .142). On multi-variable analysis, the variables significantly associated with an increased risk of both tumour progression and tumour-related death were regional lymph node and distant metastasis at admission. Survival and local control rates following RT may be comparable to radical resection. These data may better inform shared decision-making processes between multi-disciplinary care providers and owners.
(© 2020 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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