Comparative expression of cyclooxygenase 2 and Ki67 in amelanotic and conventional oral melanomas.
| Autor: | Soares CD; Department of Oral Diagnosis Piracicaba Dental School, University of Campinas Avenida Limeira, 901, Areião 13414-903 Piracicaba/SP, Brazil ciro.dss@gmail.com., Hernandez-Guerrero JC, Andrade BA, Romañach MJ, Mosqueda-Taylor A, Carlos R, Macedo MR, Almeida OP, Jorge J |
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| Jazyk: | angličtina |
| Zdroj: | Medicina oral, patologia oral y cirugia bucal [Med Oral Patol Oral Cir Bucal] 2020 Nov 01; Vol. 25 (6), pp. e728-e731. Date of Electronic Publication: 2020 Nov 01. |
| DOI: | 10.4317/medoral.23737 |
| Abstrakt: | Background: Oral melanomas have some histopathological resemblance with its cutaneous counterpart; however, an aggressive behavior is more common in tumors that occur in the oral cavity. Several markers have been suggested as indicative of tumoral progression and aggressiveness, such as cyclooxygenase 2 (COX-2) and Ki67. Material and Methods: In this study, we have compared the expression of COX-2 and Ki67 in a series of amelanotic (n=7) and melanotic oral melanomas (n=22). The cases were selected from 4 pathology laboratories and submitted to the immunohistochemical (IHC) reactions. We analyzed the IHC staining based on a qualitative - using visual scores; and a computer-assisted method (quantitative) using scanned slides and software for digital analysis. Results: COX-2 was expressed in all oral melanomas; however, its intensity was significantly higher in the amelanotic ones (P<0.001). Similarly, a high Ki67-positivity index was observed in the amelanotic than melanotic ones (P<0.001). Conclusions: Based on these results, we suggest that amelanotic oral melanomas have marked pro-inflammatory and high-proliferative phenotype, justifying their more aggressive behavior compared with the melanotic ones. |
| Databáze: | MEDLINE |
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