The sodium channel Na V 1.5 impacts on early murine embryonic cardiac development, structure and function in a non-electrogenic manner.
Autor: | Marchal GA; Department of Experimental Cardiology, Amsterdam UMC (location Academic Medical Center), Amsterdam, the Netherlands., Verkerk AO; Department of Experimental Cardiology, Amsterdam UMC (location Academic Medical Center), Amsterdam, the Netherlands.; Department of Medical Biology, Amsterdam UMC (location Academic Medical Center), Amsterdam, the Netherlands., Mohan RA; Department of Experimental Cardiology, Amsterdam UMC (location Academic Medical Center), Amsterdam, the Netherlands.; Department of Medical Biology, Amsterdam UMC (location Academic Medical Center), Amsterdam, the Netherlands., Wolswinkel R; Department of Experimental Cardiology, Amsterdam UMC (location Academic Medical Center), Amsterdam, the Netherlands., Boukens BJD; Department of Medical Biology, Amsterdam UMC (location Academic Medical Center), Amsterdam, the Netherlands., Remme CA; Department of Experimental Cardiology, Amsterdam UMC (location Academic Medical Center), Amsterdam, the Netherlands. |
---|---|
Jazyk: | angličtina |
Zdroj: | Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2020 Oct; Vol. 230 (2), pp. e13493. Date of Electronic Publication: 2020 May 27. |
DOI: | 10.1111/apha.13493 |
Abstrakt: | Aim: The voltage-gated sodium channel Na Methods: Involvement of Na Results: In WT embryos, tetrodotoxin did not affect cardiac activation at E9.5, but slowed activation at E10.5. Accordingly, patch-clamp measurements revealed that I Conclusion: We here demonstrate that Na (© 2020 The Authors. Acta Physiologica published by John Wiley & Sons Ltd on behalf of Scandinavian Physiological Society.) |
Databáze: | MEDLINE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |