Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster.

Autor: Ayikobua ET; Department of Physiology, School of Health Sciences, Soroti University, 211Soroti, Uganda.; Department of Physiology, Faculty of Health Sciences, Busitema University Mbale Campus, Box 203Mbale, Uganda.; Department of Physiology, Faculty of Biomedical Sciences, Kampala International University Western Campus, Box 71, Bushenyi, Uganda.; Institute of Biomedical Research Laboratory, Kampala International University, Western Campus, Box 71, Bushenyi, Uganda., Kasolo J; Department of Physiology, Makerere University College of health Science, Box 7072, KampalaUganda., Kasozi KI; Department of Physiology, Faculty of Biomedical Sciences, Kampala International University Western Campus, Box 71, Bushenyi, Uganda.; Institute of Biomedical Research Laboratory, Kampala International University, Western Campus, Box 71, Bushenyi, Uganda.; Department of Animal Production and Management, Faculty of Agriculture and Animal Sciences, Busitema University Arapai Campus, Box 203Soroti, Uganda., Eze ED; Department of Physiology, Faculty of Biomedical Sciences, Kampala International University Western Campus, Box 71, Bushenyi, Uganda., Safiriyu A; Department of Physiology, Faculty of Biomedical Sciences, Kampala International University Western Campus, Box 71, Bushenyi, Uganda.; Institute of Biomedical Research Laboratory, Kampala International University, Western Campus, Box 71, Bushenyi, Uganda., Ninsiima HI; Department of Physiology, Faculty of Biomedical Sciences, Kampala International University Western Campus, Box 71, Bushenyi, Uganda.; Department of Physiology, School of Medicine, Kabale University, Box 317Kabale, Uganda., Kiyimba K; Department of Pharmacology, Faculty of Pharmacy, Kampala International University Western Campus, Box 71, Bushenyi, Uganda., Namulema J; Department of Physiology, School of Health Sciences, Uzima University College - CUEA, P.O Box 2502-40100, Kisumu, Kenya., Jjesero E; Department of Physiology, Faculty of Biomedical Sciences, Kampala International University Western Campus, Box 71, Bushenyi, Uganda.; Institute of Biomedical Research Laboratory, Kampala International University, Western Campus, Box 71, Bushenyi, Uganda., Ssempijja F; Department of Anatomy, Faculty of Biomedical Sciences, Kampala International University estern Campus, Box 71, Bushenyi, Uganda., Semuyaba I; Department of Physiology, Faculty of Biomedical Sciences, Kampala International University Western Campus, Box 71, Bushenyi, Uganda., Mwandah DC; Department of Pharmacology, Faculty of Pharmacy, Kampala International University Western Campus, Box 71, Bushenyi, Uganda., Kimanje KR; Department of Biochemistry, Faculty of Biomedical Sciences, Kampala International University Western Campus, Box 71, Bushenyi, Uganda., Kalange M; Department of Physiology, Faculty of Biomedical Sciences, Kampala International University Western Campus, Box 71, Bushenyi, Uganda., Okpanachi AO; Department of Physiology, Faculty of Biomedical Sciences, Kampala International University Western Campus, Box 71, Bushenyi, Uganda.; Institute of Biomedical Research Laboratory, Kampala International University, Western Campus, Box 71, Bushenyi, Uganda., Nansunga M; Department of Physiology, Faculty of Biomedical Sciences, Kampala International University Western Campus, Box 71, Bushenyi, Uganda.; Department of Physiology, Faculty of Biomedical Sciences, St. Augustine International University, P.O Box 88, Kampala, Uganda.
Jazyk: angličtina
Zdroj: Journal of complementary & integrative medicine [J Complement Integr Med] 2020 Sep 23; Vol. 17 (3). Date of Electronic Publication: 2020 Sep 23.
DOI: 10.1515/jcim-2019-0136
Abstrakt: Background The Phosphatase and tensin-induced putative kinase 1 (PINK1B9) mutant for Drosophila melanogaster is a key tool that has been used in assessing the pathology of Parkinsonism and its possible remedy. This research was targeted toward determining the effects of ethanolic extract of propolis, with levodopa therapy in the management of Parkinsonism. Method The PINK1B9 flies were divided into groups and fed with the different treatment doses of ethanoic extract of propolis. The treatment groups were subjected to 21 days of administration of propolis and the levodopa at different doses after which percentage climbing index, antioxidant activity and lifespan studies were done. Results Propolis alone improved motor activity, antioxidant and lifespan in Drosophila melanogaster than in PINK1 flies. Propolis in combination with levodopa significantly (P<0.05) improved physiological parameters at higher than lower concentrations in Parkinsonism Drosophila melanogaster demonstrating its importance in managing side effects associated with levodopa. Conclusion Propolis is a novel candidate as an alternative and integrative medicinal option to use in the management of Parkinsonism in both animals and humans at higher concentrations.
Databáze: MEDLINE