Stress and Deformation of Optimally Shaped Silicon Microneedles for Transdermal Drug Delivery.

Autor:	Zainal Abidin HE; Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia, Bangi, Malaysia., Ooi PC; Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia, Bangi, Malaysia. Electronic address: pcooi@gmx.com., Tiong TY; Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia, Bangi, Malaysia., Marsi N; Faculty of Engineering Technology, Department of Mechanical Engineering Technology, Universiti Tun Hussein Onn Malaysia, Panchor, Johor, Malaysia., Ismardi A; Department of Engineering Physics, School of Electrical Engineering, Telkom University, Jalan Telekomunikasi Terusan Buah Batu, Bandung, Indonesia., Mohd Noor M; Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia, Bangi, Malaysia., Nik Zaini Fathi NAF; Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia, Bangi, Malaysia., Abd Aziz N; Faculty of Engineering, Department of Electrical, Electronics and Systems Engineering, Universiti Kebangsaan Malaysia, Bangi, Malaysia., Sahari SK; Faculty of Engineering, Department of Electrical and Electronic Engineering, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia., Sugandi G; Indonesian Institute of Sciences, Jakarta, Indonesia., Yunas J; Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia, Bangi, Malaysia., Dee CF; Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia, Bangi, Malaysia., Yeop Majlis B; Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia, Bangi, Malaysia., Hamzah AA; Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia, Bangi, Malaysia. Electronic address: azlanhamzah@ukm.edu.my.
Jazyk:	angličtina
Zdroj:	Journal of pharmaceutical sciences [J Pharm Sci] 2020 Aug; Vol. 109 (8), pp. 2485-2492. Date of Electronic Publication: 2020 May 05.
DOI:	10.1016/j.xphs.2020.04.019
Abstrakt:	In this study, we demonstrated the fabrication of the concave conic shape microneedle with the aid of COMSOL Multiphysics simulation. The stress and buckling of the microneedle structure were simulated by applying various loads ranging from 50 to 800 g perpendiculars to the tip in order to predict the occurrence of microneedles structure deformation. The simulation study indicated that the surface buckling deformation does not occur to the microneedle structure with the increment of the load. The microneedles with dimensions of height and diameter tip ranging from 60 to 100 μm and 1 to 4 μm, respectively had been fabricated via an etching process in a mixture of hydrofluoric acid, nitric acid, and acetic acid. Three optimized microneedles but different in the structures were fabricated via the acidic etching process. The reproducibility of 3 different microneedle structures was 15, 20, and 60%, respectively. Stress and buckling analyses of the fabricated microneedles were further carried out on the rat skin. The obtained experimental results show promising applications for the deep dermis, stratum corneum to epidermis layer penetration. (Copyright © 2020 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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