The Effect of Single High-Dose Preoperative Intravenous Tranexamic Acid Administration to Reduce Blood Loss in Patients with Primary Total Knee Replacement.

Autor:	Talmaç MA; Department of Orthopaedics, Health Sciences University Sisli Etfal Training and Research Hospital, Istanbul, Turkey., Görgel MA; Department of Orthopaedics, Health Sciences University Sisli Etfal Training and Research Hospital, Istanbul, Turkey., Birsel SE; Department of Orthopaedics, Istanbul Private Medicine Hospital, Istanbul, Turkey., Sönmez MM; Department of Orthopaedics, Health Sciences University Sisli Etfal Training and Research Hospital, Istanbul, Turkey., Özdemir HM; Department of Orthopaedics, Health Sciences University Sisli Etfal Training and Research Hospital, Istanbul, Turkey.
Jazyk:	angličtina
Zdroj:	Sisli Etfal Hastanesi tip bulteni [Sisli Etfal Hastan Tip Bul] 2019 Jun 21; Vol. 53 (2), pp. 137-142. Date of Electronic Publication: 2019 Jun 21 (Print Publication: 2019).
DOI:	10.14744/SEMB.2018.73604
Abstrakt:	Objectives: This study aimed to analyze the efficacy of single-dose tranexamic acid (TA) 20 mg/kg preoperatively to reduce blood loss in patients undergoing total knee replacement (TKR). Methods: A total of 387 patients (82 males, 305 females) undergoing TKR between January 2014 and December 2018 were included in the study. The T + group was administrated intravenous (iv) TA 20 mg/kg 20 min before the skin incision. We determined perioperative blood loss, the amount of drainage postoperative 24 h, the amount of drainage after postoperative 24-48 h, total volume of drains, total volume of blood loss, postoperative hemoglobin and hematocrit levels, and amount of total blood transfusion. Results: In terms of demographic data, no statistically significant difference was observed between the groups. Perioperative blood loss and total volume of blood loss was found statistically higher in T - group compared to T + group. Postoperatively, the mean hemoglobin and hematocrit levels of T - group were statistically significantly lower than T + group. Conclusion: A single 20 mg/kg iv TA administration before TKR reduces bleeding during surgery and within 24 h postoperatively. Competing Interests: Conflict of Interest: None declared. (Copyright: © 2019 by The Medical Bulletin of Sisli Etfal Hospital.)
Databáze:	MEDLINE
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