Hematological malignancies in East Africa-Which cancers to expect and how to provide services.

Autor: Leak SA; Cancer Care Centre, Kilimanjaro Christian Medical Centre, Moshi, United Republic of Tanzania., Mmbaga LG; Cancer Care Centre, Kilimanjaro Christian Medical Centre, Moshi, United Republic of Tanzania., Mkwizu EW; Cancer Care Centre, Kilimanjaro Christian Medical Centre, Moshi, United Republic of Tanzania., Mapendo PJ; Cancer Care Centre, Kilimanjaro Christian Medical Centre, Moshi, United Republic of Tanzania., Henke O; Cancer Care Centre, Kilimanjaro Christian Medical Centre, Moshi, United Republic of Tanzania.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2020 May 06; Vol. 15 (5), pp. e0232848. Date of Electronic Publication: 2020 May 06 (Print Publication: 2020).
DOI: 10.1371/journal.pone.0232848
Abstrakt: Background: Sub-Saharan Africa (SSA) has an increasing non-communicable disease burden. Tanzania has an incidence of more than 35,000 cancer cases per year with an 80% mortality rate. Hematological malignancies account for 10% of these cases. The numbers will double within the next 10 years due to demographic changes, better diagnostic capabilities and life style changes. Kilimanjaro Christian Medical Centre established a Cancer Care Centre (CCC) in December 2016 for a catchment area of 15 million people in Northern Tanzania. This article aims to display the hematological diagnosis and characteristics of the patients as well as to describe the advancements of hematologic services in a low resource setting.
Methods: A cross-sectional analysis of all hematological malignancies at CCC from December 2016 to May 2019 was performed and a narrative report provides information about diagnostic means, treatment and the use of synergies.
Results: A total of 209 cases have been documented, the most common malignancies were NHL and MM with 44% and 20%. 36% of NHL cases, 16% of MM cases and 63% of CML cases were seen in patients under the age of 45. When subcategorized, CLL/SLL cases had a median age was 56.5, 51 years for those with other entities of NHL. Sexes were almost equally balanced in all NHL groups while clear male predominance was found in HL and CML.
Discussion: Malignancies occur at a younger age and higher stages than in Western countries. It can be assumed that infections play a key role herein. Closing the gap of hematologic services in SSA can be achieved by adapting and reshaping existing infrastructure and partnering with international organizations.
Competing Interests: OH has received honoraria from Laborex and travel expenses Amring Pharma. For the remaining authors, no relevant conflicts of interest were declared. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje